The chemical substance known as (5Z,9β,11β,12α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid, with the CAS number 214748-66-0, is a member of the prostaglandin family, which are bioactive lipids derived from arachidonic acid. This compound features multiple hydroxyl groups, indicating its potential for strong hydrogen bonding and solubility in polar solvents. Its structure includes a series of double bonds and a carboxylic acid functional group, which contribute to its reactivity and biological activity. Prostaglandins are known for their roles in various physiological processes, including inflammation, pain modulation, and regulation of blood flow. The specific stereochemistry of this compound, denoted by the various stereocenters, is crucial for its biological function, as it influences how the molecule interacts with specific receptors in the body. Overall, this compound exemplifies the complexity and significance of prostaglandins in biochemistry and pharmacology.

Isoprostanes are produced by the non-
enzymatic, free radical peroxidation of phospholipid-
esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity.
ent
-
8-
iso
-
15(S)-
Prostaglandin F
2α
(
ent
-8-
iso
-
15(S)-
PGF
2α
) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC
50
values of 15 and 24 nM, respectively. This isoprostane is about ten-
fold more potent than 8-
iso
-
PGF
2α
in a whole blood platelet aggregation inhibition assay.

(5Z,9β,11β,12α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid

214748-66-0: The chemical substance known as (5Z,9β,11β,12α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid, with the CAS number 214748-66-0, is a member of the prostaglandin family, which are bioactive lipids derived from arachidonic acid. This compound features multiple hydroxyl groups, indicating its potential for strong hydrogen bonding and solubility in polar solvents. Its structure includes a series of double bonds and a carboxylic acid functional group, which contribute to its reactivity and biological activity. Prostaglandins are known for their roles in various physiological processes, including inflammation, pain modulation, and regulation of blood flow. The specific stereochemistry of this compound, denoted by the various stereocenters, is crucial for its biological function, as it influences how the molecule interacts with specific receptors in the body. Overall, this compound exemplifies the complexity and significance of prostaglandins in biochemistry and pharmacology.

<p>Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid.</p>

CAS 214748-66-0

(5Z,9β,11β,12α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid

ent-8-iso-15(S)-Prostaglandin F2α

Ref: TM-T35990