CAS 21498-08-8

Lofexidine hydrochloride

Description:

Lofexidine hydrochloride is a medication primarily used for the management of opioid withdrawal symptoms. It is an alpha-2 adrenergic agonist, which means it works by stimulating alpha-2 receptors in the central nervous system, leading to reduced sympathetic outflow and alleviation of withdrawal symptoms. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration. Its chemical formula reflects the presence of a hydrochloride salt, which enhances its stability and solubility. Lofexidine is known for its relatively favorable side effect profile compared to other medications used in opioid withdrawal, although it can still cause sedation, hypotension, and bradycardia. The pharmacokinetics of lofexidine indicate that it has a moderate half-life, allowing for twice-daily dosing in clinical settings. Overall, lofexidine hydrochloride serves as an important therapeutic option in the context of opioid dependence treatment, providing a non-opioid alternative to ease withdrawal symptoms.

Formula: C₁₁H₁₂Cl₂N₂O·ClH

InChI: InChI=1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H

InChI key: InChIKey=DWWHMKBNNNZGHF-UHFFFAOYSA-N

SMILES: O(C(C)C=1NCCN1)C2=C(Cl)C=CC=C2Cl.Cl

Synonyms:

• (±)-2-(1-(2,6-Dichlorophenoxy)ethyl)-2-imidazoline Hydrochloride
• 1H-Imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-, monohydrochloride
• 1H-imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-, hydrochloride (1:1)
• 2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole Monohydrochloride
• 2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole hydrochloride
• 2-Imidazoline, 2-[1-(2,6-dichlorophenoxy)ethyl]-, monohydrochloride
• 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole hydrochloride (1:1)
• Baq 168
• Britlofex
• Lofetensin
• Loxacor
• Mdl 14042
• Rmi 14042A

Lofexidine hydrochloride, 98+%

CAS: 21498-08-8

Alpha-2 adrenergic agonist

Formula: C₁₁H₁₂Cl₂N₂O•HCl

Purity: 98+%

Molecular weight: 295.6

Ref: 02-J63960

Lofexidine hydrochloride

CAS: 21498-08-8

Formula: C₁₁H₁₂Cl₂N₂OHCl

Purity: ≥ 98.0%

Color and Shape: White to beige powder

Molecular weight: 295.60

Ref: 7W-GP5420

Lofexidine Hydrochloride

Controlled Product

CAS: 21498-08-8

Formula: C₁₁H₁₂Cl₂N₂O·ClH

Color and Shape: Neat

Molecular weight: 295.59

Ref: 86-MM1898.00

Lofexidine Hydrochloride

Controlled Product

CAS: 21498-08-8

Applications α2-Adrenoceptor agonist related structurally to Clonidine. Used in treatment of opioid withdrawal symptoms; antihypertensive.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Velly, J., et al.: J. Pharmacol., 8, 351 (1977), Jarrot, B., et al.: Biochem. Pharmacol., 28, 141 (1979), Birch, P., at al.: Brit. J. Pharmacol., 68, 107 (1980),

Formula: C₁₁H₁₂Cl₂N₂O·ClH

Color and Shape: Neat

Molecular weight: 295.59

Ref: TR-L469390

Lofexidine hydrochloride

CAS: 21498-08-8

α2-adrenergic receptor agonist; used for the treatment of opiate withdrawal

Formula: C₁₁H₁₃Cl₃N₂O

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 295.59 g/mol

Ref: 3D-FL24920

Lofexidine HCl - Bio-X ™

CAS: 21498-08-8

Lofexidine is a drug that belongs to the group of α2-adrenergic receptor antagonists. It has been shown to reduce the symptoms of withdrawal from opiates and cocaine, as well as alcohol and nicotine. This drug inhibits the enzyme cAMP which catalyzes the conversion of dopamine to norepinephrine by preventing it from binding to its receptor site on cells.

Formula: C₁₁H₁₂Cl₂N₂O•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 295.59 g/mol

Ref: 3D-FL65064

Lofexidine Hydrochloride

CAS: 21498-08-8

Color and Shape: Neat

Ref: 61-FOR1898.00