CAS 2158201-04-6

4-(Difluoromethyl)-1-(4-fluorophenyl)-5-phenyl-N-[[2-(2,2,2-trifluoroethoxy)phenyl]methyl]-1H-pyrazole-3-carboxamide

Formula: C₂₆H₁₉F₆N₃O₂

Synonyms:

• 4-(Difluoromethyl)-1-(4-fluorophenyl)-5-phenyl-N-[[2-(2,2,2-trifluoroethoxy)phenyl]methyl]-1H-pyrazole-3-carboxamide

Cav 3.1 blocker 1

CAS: 2158201-04-6

Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel inhibitor with an IC50 value of 160 nM for Cav3.1. It exhibits weaker inhibition on Cav 3.2 with an IC50 of 5000 nM and shows no inhibitory effect on Cav 3.3 and Cav 1.2 (IC50 > 10000 nM).

Formula: C₂₆H₁₉F₆N₃O₂

Molecular weight: 519.438

Ref: TM-T204798