CAS 2162952-37-4

PMMB-187

Description:

As of my last update in October 2023, PMMB-187, identified by the CAS number 2162952-37-4, is a synthetic compound that has garnered attention in the field of medicinal chemistry and pharmacology. While specific details about its characteristics may not be widely available, compounds like PMMB-187 are typically evaluated for their molecular structure, solubility, stability, and biological activity. Such substances are often studied for their potential therapeutic applications, including their efficacy and safety profiles in various biological systems. The characteristics of PMMB-187 would likely include its molecular weight, functional groups, and potential interactions with biological targets. Additionally, researchers would assess its pharmacokinetics, including absorption, distribution, metabolism, and excretion (ADME) properties. For precise and detailed information, including experimental data and specific applications, consulting scientific literature or databases dedicated to chemical substances would be essential.

Formula: C₂₇H₂₃BrN₂O₆S₂

Synonyms:

• Acetic acid, 2-[[5-[(4-bromophenyl)methyl]-1,3,4-thiadiazol-2-yl]thio]-, (1R)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl)-4-methyl-3-penten-1-yl ester
• PMMB-187

PMMB-187

CAS: 2162952-37-4

PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.

Formula: C₂₇H₂₃BrN₂O₆S₂

Color and Shape: Solid

Molecular weight: 615.52

Ref: TM-T200126