CAS 2163769-52-4

2-Cyano-4-methyl-5-[[2-[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]-2,7-diazaspiro[3.5]non-7-yl]methyl]-1H-indole-1-acetamide

Formula: C₂₈H₂₈F₃N₇OS

Synonyms:

• 2-[2-Cyano-4-methyl-5-[[2-[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]-2,7-diazaspiro[3.5]nonan-7-yl]methyl]-1-indolyl]acetamide
• 2-Cyano-4-methyl-5-[[2-[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]-2,7-diazaspiro[3.5]non-7-yl]methyl]-1H-indole-1-acetamide
• BAY-155

BAY-155

CAS: 2163769-52-4

BAY-155 is a powerful and selective menin-MLL inhibitor, exhibiting an IC 50 of 8 nM. It significantly down-regulates MEIS1 gene expression while up-regulating CD11b and MNDA genes. BAY-155 also demonstrates anti-proliferative effects in AML/ALL (acute myeloid/lymphoblastic leukemia) models [1].

Formula: C₂₈H₂₈F₃N₇OS

Color and Shape: Solid

Molecular weight: 567.63

Ref: TM-T85802