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CAS 216503-57-0

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Immunoglobulin G1,anti-(human CD52 (antigen)) (human-rat monoclonal CAMPATH-1H g1-chain), disulfide withhuman-rat monoclonal CAMPATH-1H light chain, dimer

Description:
Immunoglobulin G1, anti-(human CD52 (antigen)), commonly known as CAMPATH-1H, is a monoclonal antibody that targets the CD52 antigen, which is predominantly expressed on the surface of certain immune cells, including T and B lymphocytes. This antibody is a human-rat chimeric IgG1, meaning it combines human and rat immunoglobulin components, enhancing its therapeutic efficacy while minimizing immunogenicity. The structure of this antibody includes a dimeric form, consisting of two heavy chains linked by disulfide bonds, along with two light chains, which are also linked by disulfide bonds. CAMPATH-1H is primarily used in the treatment of certain hematological malignancies, such as chronic lymphocytic leukemia (CLL), and in conditioning regimens prior to stem cell transplantation. Its mechanism of action involves the induction of apoptosis in CD52-expressing cells and the modulation of the immune response. As a therapeutic agent, it is administered under strict medical supervision due to potential side effects, including infusion reactions and immunosuppression.
Synonyms:
  • Alemtuzumab
  • CamPath
  • Campath 1H
  • Campath 1H/LDP03
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Found 2 products.
  • CymitQuimica logo
    Targetmol
    + Info

    Alemtuzumab

    CAS:
    <p>Alemtuzumab is a humanized monoclonal antibody against CD52 an antigen found on the surface of normal and malignant lymphocytes.</p>
    Purity:97.2% (SDS-PAGE); 96.7% (SEC-HPLC) - 98.00%
    Color and Shape:Liquid
    Molecular weight:146.04 kDa

    Ref: TM-T9919

  • Alemtuzumab
    Biosynth
    + Info

    Alemtuzumab

    CAS:
    <p>Monoclonal antibody against CD52; treatment for multiple sclerosis; anti-cancer</p>
    Purity:Min. 95 Area-%
    Color and Shape:Colorless Clear Liquid

    Ref: 3D-BA165581

    1mg
    929.00€