(S)-IDO1-IN-5, with the CAS number 2166616-76-6, is a chemical compound that serves as an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme involved in the metabolism of tryptophan and immune regulation. This compound is characterized by its chiral nature, as indicated by the "(S)" prefix, which denotes its specific stereochemistry. IDO1 plays a significant role in immune evasion by tumors, making inhibitors like (S)-IDO1-IN-5 of interest in cancer therapy and immunotherapy research. The compound's structure typically includes functional groups that facilitate its interaction with the enzyme's active site, enhancing its inhibitory potency. Additionally, (S)-IDO1-IN-5 may exhibit properties such as solubility in organic solvents and potential bioactivity, which are crucial for its application in biological systems. As research progresses, understanding its pharmacokinetics, efficacy, and safety profile will be essential for its development as a therapeutic agent.

(S)-IDO1-IN-5 is the S-isomer of IDO1-IN-5. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[1].

(S)-IDO1-IN-5

2166616-76-6: (S)-IDO1-IN-5, with the CAS number 2166616-76-6, is a chemical compound that serves as an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme involved in the metabolism of tryptophan and immune regulation. This compound is characterized by its chiral nature, as indicated by the "(S)" prefix, which denotes its specific stereochemistry. IDO1 plays a significant role in immune evasion by tumors, making inhibitors like (S)-IDO1-IN-5 of interest in cancer therapy and immunotherapy research. The compound's structure typically includes functional groups that facilitate its interaction with the enzyme's active site, enhancing its inhibitory potency. Additionally, (S)-IDO1-IN-5 may exhibit properties such as solubility in organic solvents and potential bioactivity, which are crucial for its application in biological systems. As research progresses, understanding its pharmacokinetics, efficacy, and safety profile will be essential for its development as a therapeutic agent.

<p>(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 μΜ).</p>

CAS 2166616-76-6

(S)-IDO1-IN-5

(S)-IDO1-IN-5

Ref: TM-T12801