CAS 21679-14-1

Fludarabine

Description:

Fludarabine is a synthetic purine nucleoside analog primarily used in the treatment of certain types of hematological malignancies, particularly chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma. Its chemical structure consists of a ribonucleoside with a fluorine atom substituted at the 2' position of the sugar moiety, which enhances its stability and efficacy. Fludarabine is known for its mechanism of action, which involves the inhibition of DNA synthesis and repair, leading to apoptosis in rapidly dividing cancer cells. It is typically administered intravenously or orally and is often used in combination with other chemotherapeutic agents to improve therapeutic outcomes. The substance is characterized by its relatively low toxicity profile compared to traditional chemotherapeutics, although it can still cause side effects such as immunosuppression and myelosuppression. Due to its specific targeting of lymphoid cells, Fludarabine has become a critical component in the management of certain leukemias and lymphomas, contributing to improved patient survival rates.

Formula: C₁₀H₁₂FN₅O₄

InChI: InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1

InChI key: InChIKey=HBUBKKRHXORPQB-FJFJXFQQSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)=NC(F)=N1

Synonyms:

• 2-Fluoro Ara-A
• 2-Fluoro-9-β-<span class="text-smallcaps">D</span>-arabinofuranosyladenine
• 2-Fluoro-9-β-D-arabinofuranosyladenine
• 2-Fluoroadenine arabinoside
• 2-Fluoroadenine-9-bata-D-arabinofuranoside
• 2F-Ara-A
• 9-(beta-D-arabinofuranosyl)-2-fluoro-9H-purin-6-amine
• 9-bata-D-Arabinofuranosyl-2-fluoroadenine
• 9-beta-D-Arabinofuranosyl-2-fluoroadenine
• 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
• 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosyl-2-fluoroadenine
• 9-β-<span class="text-smallcaps">D</span>-Arabinosyl-2-fluoroadenine
• 9-β-D-Arabinofuranosyl-2-fluoroadenine
• 9-β-D-Arabinosyl-2-fluoroadenine
• 9H-Purin-6-amine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-2-fluoro-
• 9H-Purin-6-amine, 9-β-D-arabinofuranosyl-2-fluoro-
• Adenine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-2-fluoro-
• Adenine, 9-β-D-arabinofuranosyl-2-fluoro-
• F-ara-A
• Fludarabin
• Fludarabina
• Fludarabine base
• Nsc 118218
• Nsc 118218H

Fludarabine

CAS: 21679-14-1

Formula: C₁₀H₁₂FN₅O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 285.24

Ref: 3B-F0658

2-Fluoro-9-β-D-arabinofuranosyladenine, 98%

CAS: 21679-14-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₀H₁₂FN₅O₄

Purity: 98%

Molecular weight: 285.23

Ref: 02-J65562

Fludarabine

CAS: 21679-14-1

Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.

Formula: C₁₀H₁₂FN₅O₄

Purity: 99.65% - 99.89%

Color and Shape: White Solid

Molecular weight: 285.23

Ref: TM-T1038

9-b-D-Arabinofuranosyl-2-fluoroadenine

CAS: 21679-14-1

Formula: C₁₀H₁₂FN₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 285.2318

Ref: IN-DA0039PU

Fludarabine

CAS: 21679-14-1

Fludarabine

Purity: ≥98%

Molecular weight: 285.23g/mol

Ref: 54-BUP15092

Fludarabine

CAS: 21679-14-1

Fludarabine

Purity: 98%

Molecular weight: 285.23g/mol

Ref: 54-PC108826

Fludarabine

CAS: 21679-14-1

Formula: C₁₀H₁₂FN₅O₄

Molecular weight: 285.23

Ref: 7W-GP0730

Fludarabine (Fludarabine Phosphate EP Impurity E)

CAS: 21679-14-1

Formula: C₁₀H₁₂FN₅O₄

Color and Shape: White To Off-White Solid

Molecular weight: 285.24

Ref: 4Z-F-587

Fludarabine

CAS: 21679-14-1

Color and Shape: Neat

Ref: 86-MM3428.05

Fludarabine

CAS: 21679-14-1

Applications Used as an antineoplastic.
References Brockman, R.W., et al.: Biochem. Pharmacol., 26, 2193 (1977), Brockman, R.W., et al.: Cancer Res., 40, 3610 (1980), Chun, H.G., et al.: Cancer Treat. Rep., 70, 1225 (1986), Warrell, R.P., et al.: J. Clin. Oncol., 4, 74 (1986),

Formula: C₁₀H₁₂FN₅O₄

Color and Shape: Neat

Molecular weight: 285.23

Ref: TR-F425000

Fludarabine

CAS: 21679-14-1

Fludarabine is a purine analog and works by interfering with DNA synthesis, which helps to stop the growth of cancer cells.

Formula: C₁₀H₁₂FN₅O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 285.23 g/mol

Ref: 3D-NF05140

(2R,3S,4S,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

CAS: 21679-14-1

Formula: C₁₀H₁₂FN₅O₄

Purity: 95%

Color and Shape: Solid, White powder

Molecular weight: 285.235

Ref: 10-F079410

Fludarabine-13C2,15N

CAS: 21679-14-1

Formula: C₂C₈H₁₂F₁₅NN₄O₄

Color and Shape: Neat

Molecular weight: 288.211

Ref: TR-F425002

Fludarabine Arabinosyl-13C5

Controlled Product

CAS: 21679-14-1

Formula: C₅C₅H₁₂FN₅O₄

Color and Shape: Neat

Molecular weight: 290.195

Ref: TR-F425003

Fludarabine Phosphate EP Impurity E

CAS: 21679-14-1

Formula: C₁₀H₁₂FN₅O₄

Molecular weight: 285.24

Ref: ST-EA-CP-F71005