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CAS 216973-69-2

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Carvedilol N-β-D-Glucuronide

Description:
Carvedilol N-β-D-Glucuronide is a metabolite of carvedilol, a non-selective beta-blocker used primarily for the treatment of hypertension and heart failure. This compound is characterized by its glucuronide conjugation, which enhances its solubility and facilitates excretion. The chemical structure features a glucuronic acid moiety linked to the carvedilol molecule, which is known for its antioxidant properties and ability to improve cardiac function. The glucuronidation process typically occurs in the liver and is a common phase II metabolic reaction that aids in detoxifying and eliminating drugs from the body. Carvedilol N-β-D-Glucuronide is generally less pharmacologically active than its parent compound but can still play a role in the overall pharmacokinetics of carvedilol. Its presence in biological fluids can be indicative of carvedilol metabolism and may be relevant in pharmacokinetic studies. Understanding the characteristics of this metabolite is essential for comprehending the drug's efficacy, safety profile, and potential interactions in clinical settings.
Formula:C30H34N2O10
Synonyms:
  • Carvedilol N-2-D-Glucuronide
  • β-D-Glucopyranuronic acid, 1-deoxy-1-[4-[2-hydroxy-3-[[2-(2-methoxyphenoxy)ethyl]amino]propoxy]-9H-carbazol-9-yl]-
  • Carvedilol N-beta-D-Glucuronide
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Found 2 products.
  • Carvedilol-d3 N-β-D-Glucuronide
    TRC
    + Info

    Carvedilol-d3 N-β-D-Glucuronide

    Controlled Product
    CAS:
    <p>Applications Carvedilol-d3 N-β-D-Glucuronide is the labeled analogue of Carvedilol N-β-D-Glucuronide (C184615), a metabolite of Carvedilol (C184625); a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is also an antihypertensive used in the treatment of congestive heart failure.<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990); Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996)<br></p>
    Formula:C30D3H31N2O10
    Color and Shape:Neat
    Molecular weight:585.617

    Ref: TR-C184617

    10mg
    10,660.00€
  • Carvedilol N-β-D-Glucuronide
    TRC
    + Info

    Carvedilol N-β-D-Glucuronide

    Controlled Product
    CAS:
    Formula:C30H34N2O10
    Color and Shape:Neat
    Molecular weight:582.598

    Ref: TR-C184615

    5mg
    2,058.00€