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CAS 217087-09-7

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Esomeprazole magnesium trihydrate

Description:
Esomeprazole magnesium trihydrate is a proton pump inhibitor primarily used to treat gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid production. It is the magnesium salt of the S-enantiomer of omeprazole, which enhances its bioavailability and therapeutic efficacy. This compound is characterized by its white to off-white crystalline appearance and is soluble in water, which facilitates its absorption in the gastrointestinal tract. The trihydrate form indicates that it contains three molecules of water, contributing to its stability and solubility. Esomeprazole magnesium trihydrate works by irreversibly inhibiting the H+/K+ ATPase enzyme in the gastric parietal cells, leading to a decrease in gastric acid secretion. Its pharmacokinetics involve rapid absorption, with peak plasma concentrations typically occurring within a few hours after administration. Common side effects may include headache, nausea, and abdominal pain, while long-term use has been associated with potential risks such as vitamin B12 deficiency and gastrointestinal infections. Overall, esomeprazole magnesium trihydrate is an effective medication for managing acid-related disorders.
Formula:C34H42MgN6O9S2
InChI:InChI=1/2C17H18N3O3S.Mg.3H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;;;/h2*5-8H,9H2,1-4H3;;3*1H2/q2*-1;+2;;;
Synonyms:
  • Bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzylimidazole-1-yl) magnesium trihydrate
  • Magnesium 5-Methoxy-2-{[(4-Methoxy-3,5-Dimethylpyridin-2-Yl)Methyl]Sulfinyl}Benzimidazol-1-Ide Hydrate (1:2:3)
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