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CAS 217087-10-0

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Esomeprazole magnesium dihydrate

Description:
Esomeprazole magnesium dihydrate is a proton pump inhibitor primarily used to treat gastroesophageal reflux disease (GERD) and other conditions associated with excessive stomach acid production. It is the magnesium salt of the S-enantiomer of omeprazole, which enhances its pharmacological efficacy. This compound is characterized by its ability to inhibit the H+/K+ ATPase enzyme in the gastric parietal cells, leading to a reduction in gastric acid secretion. Esomeprazole magnesium dihydrate is typically presented as a white to off-white crystalline powder, which is soluble in water and exhibits stability under normal conditions. The dihydrate form indicates the presence of two water molecules associated with each magnesium esomeprazole unit, which can influence its solubility and bioavailability. In terms of safety, it is generally well-tolerated, though potential side effects may include headache, nausea, and gastrointestinal disturbances. As with any medication, it is essential to use esomeprazole under medical supervision to ensure appropriate dosing and to monitor for any adverse reactions.
Formula:C34H40MgN6O8S2
InChI:InChI=1/2C17H18N3O3S.Mg.2H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;;/h2*5-8H,9H2,1-4H3;;2*1H2/q2*-1;+2;;
Synonyms:
  • (S)-Omeprazole Magnesium Dihydrate, Nexium Dihydrate, (T-4)-Bis[6-Methoxy-2-[(S)-[(4-Methoxy-3,5-Dimethyl-2-Pyridinyl)Methyl]Sulfinyl-Ko]-1H-Benzimidazolato-Kn3]-Magnesium Dihydrate
  • Esomeprazole Mg di-hydrate
  • (S)-Omeprazole magnesium dihydrate, Nexium dihydrate, (T-4)-Bis[6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl-KO]-1H-benzimidazolato-KN3]-
  • (S)-Omeprazole magnesium dihydrate
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