CAS 217178-62-6

5'-O-[(4-Bromophenoxy)(O-methyl-L-alanino)phosphoryl]-3'-deoxy-2',3'-didehydrothymidine

Description:

The chemical substance known as "5'-O-[(4-Bromophenoxy)(O-methyl-L-alanino)phosphoryl]-3'-deoxy-2',3'-didehydrothymidine," with the CAS number 217178-62-6, is a modified nucleoside analog. This compound features a thymidine backbone, which is a component of DNA, but is structurally altered to enhance its biological activity or stability. The presence of a phosphoryl group linked to a phenoxy moiety suggests potential interactions with biological systems, possibly influencing cellular uptake or enzymatic activity. The O-methyl-L-alanino group may contribute to its solubility and bioavailability. The bromophenyl substituent can also impart unique electronic properties, potentially affecting the compound's reactivity and interaction with target biomolecules. Such modifications are often designed to improve the efficacy of nucleoside analogs in therapeutic applications, particularly in antiviral or anticancer treatments. Overall, this compound exemplifies the intricate design of synthetic nucleosides aimed at enhancing pharmacological properties while maintaining a structural resemblance to natural nucleotides.

Formula: C₂₀H₂₃BrN₃O₈P

InChI: InChI=1/C20H23BrN3O8P/c1-12-10-24(20(27)22-18(12)25)17-9-8-16(31-17)11-30-33(28,23-13(2)19(26)29-3)32-15-6-4-14(21)5-7-15/h4-10,13,16-17H,11H2,1-3H3,(H,23,28)(H,22,25,27)/t13-,16-,17+,33?/m0/s1

Synonyms:

• Stampidine
• HI-113
• methyl (2R)-2-[[(4-bromophenoxy)-[[(2S,5R)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methoxy]phosphoryl]amino]propanoate
• methyl N-[(4-bromophenoxy){[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl]methoxy}phosphoryl]-L-alaninate
• d4T-pBPMAP
• STAMP
• Sampidine

Stampidine

CAS: 217178-62-6

Stampidine prevents HIV-1, effective against resistant strains at subnanomolar levels.

Formula: C₂₀H₂₃BrN₃O₈P

Purity: 98%

Color and Shape: Solid

Molecular weight: 544.29

Ref: TM-T24839