CAS 2181-04-6

Canrenoate potassium

Description:

Canrenoate potassium is a potassium salt of canrenone, primarily used as a diuretic and antihypertensive agent. It is classified as a potassium-sparing diuretic, which means it helps the body eliminate excess fluid while retaining potassium, an essential electrolyte. The substance is typically administered in the form of tablets or injections and is often prescribed for conditions such as hypertension, edema, and certain hormonal disorders. Canrenoate potassium works by antagonizing aldosterone, a hormone that promotes sodium retention and potassium excretion, thereby facilitating increased urine production and reducing blood pressure. The compound is known for its relatively low side effect profile compared to other diuretics, making it a preferred choice in certain clinical scenarios. In terms of physical properties, canrenoate potassium is generally a white to off-white crystalline powder, soluble in water, and stable under normal conditions. As with any medication, it is important to use canrenoate potassium under medical supervision to monitor for potential interactions and side effects.

Formula: C₂₂H₃₀O₄·K

InChI: InChI=1S/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/t16-,17+,18+,20+,21+,22-;/m1./s1

InChI key: InChIKey=OCNCAPJTFQNUKP-RYVBEKKQSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(C=C3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@]2(CCC(O)=O)O)[H].[K]

Synonyms:

• 17-Hydroxy-3-oxo-17α-pregna-4,6-diene-21-carboxylic acid potassium salt
• 17α-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, monopotassium salt
• 17α-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, potassium salt
• Aldadiene Kalium
• Aldadiene potassium
• Aldadiene potassium salt
• Canrenoate Potassium
• Cb 8109
• Kanrenol
• MF 465 a
• Potassium 17-hydroxy-3-oxo-17α-pregna-4,6-diene-21-carboxylate
• Potassium 3-(17β-hydroxy-3-oxoandrosta-4,6-dien-17-yl)propionate
• Potassium 3-(3-oxo-17β-hydroxy-4,6-androstadien-17α-yl)propionate
• Potassium aldadiene
• Potassium canrenoate
• Potassium β-(3-oxo-17β-hydroxyandrosta-4,6-dien-17α-yl)propionate
• Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, monopotassium salt, (17α)-
• Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, potassium salt (1:1), (17α)-
• Sc 14266
• Sc 14266/371
• Soldactona
• Soldactone
• Soludactone
• Venactone
• potassium 3-[(10R,13S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoate (non-preferred name)

Canrenoic acid potassium salt, 98+%

CAS: 2181-04-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₂₂H₂₉KO₄

Purity: 98+%

Molecular weight: 396.57

Ref: 02-J61394

Canrenoate (potassium)

CAS: 2181-04-6

Formula: C₂₂H₃₀KO₄

Purity: 96%

Color and Shape: Solid

Molecular weight: 397.5695

Ref: IN-DA003TVY

Canrenoate potassium

CAS: 2181-04-6

Canrenoate potassium

Purity: ≥95%

Molecular weight: 396.56g/mol

Ref: 54-BUP17538

Potassium Canrenoate

CAS: 2181-04-6

Formula: C₂₂H₂₉KO₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 396.57

Ref: 3B-C3854

Canrenoate potassium

CAS: 2181-04-6

Canrenoate potassium (Soldactone) is a synthetic pregnadiene derivative with anti-aldosterone activity.

Formula: C₂₂H₂₉KO₄

Purity: 99.04% - 99.18%

Color and Shape: Light Yellow To Tan Powder

Molecular weight: 396.56

Ref: TM-T3096

Canrenoic Acid Potassium Salt

Controlled Product

CAS: 2181-04-6

Applications Canrenoic acid is an aldosterone antagonist. Canrenoic acid is used as an diuretic.
References Sadee, W., et al.: J. Pharm. Sci., 61, 1126 (1972), Peterfalvi, M., et al.: Biochem. Pharmacol., 29, 353 (1980), Los, L., et al.: Drug Metab. Dispos., 21, 1086 (1993), Ter Heine, R., et al.: J. Pharm. Biomed. Anal., 49, 451 (2009),

Formula: C₂₂H₂₉KO₄

Color and Shape: Off-White To Light Yellow

Molecular weight: 396.56

Ref: TR-C175625

Potassium canrenoate

Controlled Product

CAS: 2181-04-6

Potassium canrenoate is a potassium salt of canrenoic acid, which is an imidazopyridine that has been shown to be beneficial in the treatment of cardiovascular diseases. It binds to the adenyl cyclase receptor, inhibiting production of cyclic AMP, and thereby decreasing the uptake of glucose and fatty acids into muscle cells. In addition, potassium canrenoate increases blood flow by dilating coronary arteries, improves cardiac contractility and reduces myocardial oxygen demand. The hyperglycemic effect seen with potassium canrenoate may be due to its ability to inhibit insulin release from pancreatic beta-cells.

Formula: C₂₂H₂₉KO₄

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 396.56 g/mol

Ref: 3D-FP149848

Potassium canrenoate

CAS: 2181-04-6

Formula: C₂₂H₂₉KO₄

Purity: ≥96%

Molecular weight: 396.568

Ref: 10-F241687

Canrenoic Acid Potassium Salt

CAS: 2181-04-6

Formula: C₂₂H₂₉O₄K

Molecular weight: 357.47 : 39.10

Ref: ST-EA-CP-A321007