CAS 21820-51-9

Phospho-L-tyrosine

Description:

Phospho-L-tyrosine is a phosphorylated derivative of the amino acid tyrosine, characterized by the addition of a phosphate group to the hydroxyl (-OH) group of the tyrosine side chain. This modification plays a crucial role in cellular signaling and protein function, particularly in the context of phosphorylation events that regulate various biological processes. Phospho-L-tyrosine is often involved in signal transduction pathways, influencing processes such as cell growth, differentiation, and metabolism. The compound is typically soluble in water and exhibits a polar nature due to the presence of the phosphate group, which enhances its reactivity and interaction with other biomolecules. Its presence in proteins can significantly alter their activity and interactions, making it a key player in the regulation of enzymatic functions and cellular responses. Phospho-L-tyrosine is commonly used in biochemical research, particularly in studies related to tyrosine kinase activity and the role of phosphorylation in cellular mechanisms.

Formula: C₉H₁₂NO₆P

InChI: InChI=1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1

InChI key: InChIKey=DCWXELXMIBXGTH-QMMMGPOBSA-N

SMILES: O(P(=O)(O)O)C1=CC=C(C[C@@H](C(O)=O)N)C=C1

Synonyms:

• (2S)-2-Amino-3-(4-phosphonooxyphenyl)propanoic acid
• <span class="text-smallcaps">L</span>-Phosphotyrosine
• <span class="text-smallcaps">L</span>-Tyrosine, O-phosphono-
• <span class="text-smallcaps">L</span>-Tyrosine, dihydrogen phosphate (ester)
• <span class="text-smallcaps">L</span>-Tyrosine-O-phosphate
• H-Tyr(PO3)-OH
• N-phosphonotyrosine
• O-Phospho-<span class="text-smallcaps">L</span>-tyrosine
• O-Phosphono-<span class="text-smallcaps">L</span>-tyrosine
• O-Phosphotyrosine
• O-phosphono-L-tyrosine
• Phospho-<span class="text-smallcaps">L</span>-tyrosine
• Phosphotyrosine
• Tyrosine O-phosphate
• Tyrosine, di-H phosphate
• Tyrosine, dihydrogen phosphate (ester), <span class="text-smallcaps">L</span>-
• Tyrosine, phosphate
• L-Tyrosine, dihydrogen phosphate (ester)
• Tyrosine, dihydrogen phosphate (ester), L-

O-Phospho-L-tyrosine

CAS: 21820-51-9

Formula: C₉H₁₂NO₆P

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 261.17

Ref: 3B-P0959

H-Tyr(PO₃H₂)-OH

CAS: 21820-51-9

L-Phosphotyrosine can be used in the detection and quantification of tyrosine phosphorylation in proteins and as starting material in the synthesis of fluorescent substrates for protein tyrosine phosphatase assays. Furthermore, it has been incorporated in cyclic hexapeptides for studying intramolecular quenching of tryptophan fluorescence. L-Phosphotyrosine inhibits cellular growth by activating protein tyrosine phosphatases (Mishra and Hamburger). The phosphorylated amino acid protects TP53 wild-type cells against ionizing radiation.

Formula: C₉H₁₂NO₆P

Purity: > 99%

Color and Shape: Whitish Powder

Molecular weight: 261.17

Ref: 01-4025464

O-PHOSPHO-L-TYROSINE

CAS: 21820-51-9

Formula: C₉H₁₂NO₆P

Purity: 95%

Color and Shape: Solid

Molecular weight: 261.1684

Ref: IN-DA003THO

O-Phospho-L-tyrosine

CAS: 21820-51-9

Formula: C₉H₁₂NO₆P

Purity: ≥ 95.0%

Color and Shape: White to off-white powder

Molecular weight: 261.17

Ref: 7W-GM6522

H-Tyr(H2PO3)-OH

CAS: 21820-51-9

H-Tyr(H2PO3)-OH

Purity: 98%

Molecular weight: 261.17g/mol

Ref: 54-OR1007549

O-Phospho-L-tyrosine

CAS: 21820-51-9

Applications Useful in the study of tyrosine-phosphorylation, which has been linked with the malignant transformation of cells by some RNA tumour viruses.
References Sefton, B.M., et al.: Cell, 20, 807 (1980), Erikson, R., et al.: Perspect. Virol., 11, 93 (1981), Lee, E-S, et al.: J. Org. Chem., 59, 2086 (1994)

Formula: C₉H₁₂NO₆P

Color and Shape: Neat

Molecular weight: 261.17

Ref: TR-P365000

O-Phospho-L-tyrosine

CAS: 21820-51-9

Formula: C₉H₁₂NO₆P

Purity: 98%

Color and Shape: Solid

Molecular weight: 261.17

Ref: 10-F493251

O-Phospho-L-tyrosine

CAS: 21820-51-9

O-Phospho-L-tyrosine is a phosphorylated form of L-tyrosine. It is used as an immunogen in the production of monoclonal antibodies. O-Phospho-L-tyrosine has also been shown to inhibit the enzyme indole alkaloids, which are responsible for the development of oral pathogens. The dephosphorylation of O-Phospho-L-tyrosine by tyrosine phosphatases leads to its conversion back to L-tyrosine. This compound can be detected by chromatographic analysis and is commonly used in analytical methods to identify natural compounds.

Formula: C₉H₁₂NO₆P

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 261.17 g/mol

Ref: 3D-FP27018