APN-C3-PEG4-alkyne, identified by the CAS number 2183440-36-8, is a synthetic compound that belongs to the class of polyethylene glycol (PEG) derivatives. It features a propargyl group, which is an alkyne functional group, allowing for potential applications in click chemistry and bioconjugation. The structure typically includes a three-carbon (C3) spacer that connects the alkyne to the PEG moiety, enhancing solubility and biocompatibility. PEG compounds are known for their hydrophilic properties, which can improve the pharmacokinetics of drugs and facilitate the formation of stable conjugates with biomolecules. The alkyne functionality enables selective reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it valuable in various fields, including drug delivery, materials science, and biochemistry. Overall, APN-C3-PEG4-alkyne is characterized by its versatility in chemical reactions, solubility in aqueous environments, and potential for use in advanced therapeutic and diagnostic applications.

APN-C3-PEG4-alkyne is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and an alkyne group. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation.

APN-C3-PEG4-alkyne

2183440-36-8: APN-C3-PEG4-alkyne, identified by the CAS number 2183440-36-8, is a synthetic compound that belongs to the class of polyethylene glycol (PEG) derivatives. It features a propargyl group, which is an alkyne functional group, allowing for potential applications in click chemistry and bioconjugation. The structure typically includes a three-carbon (C3) spacer that connects the alkyne to the PEG moiety, enhancing solubility and biocompatibility. PEG compounds are known for their hydrophilic properties, which can improve the pharmacokinetics of drugs and facilitate the formation of stable conjugates with biomolecules. The alkyne functionality enables selective reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it valuable in various fields, including drug delivery, materials science, and biochemistry. Overall, APN-C3-PEG4-alkyne is characterized by its versatility in chemical reactions, solubility in aqueous environments, and potential for use in advanced therapeutic and diagnostic applications.

<p>APN-C3-PEG4-alkyne is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

CAS 2183440-36-8

APN-C3-PEG4-alkyne

APN-C3-PEG4-alkyne

Ref: TM-T14309