CAS 2191110-79-7

2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]-

Description:

2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]- is a chemical compound characterized by its unique structure, which includes a propenone functional group and a spirocyclic moiety. The presence of the diazaspiro structure indicates that it contains two nitrogen atoms within a spirocyclic framework, contributing to its potential biological activity and complexity. The phenylmethyl group attached to the spiro structure enhances its lipophilicity, which may influence its solubility and interaction with biological systems. This compound may exhibit interesting reactivity due to the α,β-unsaturated carbonyl group, making it a potential candidate for various chemical reactions, including Michael additions and Diels-Alder reactions. Its specific properties, such as melting point, boiling point, and spectral characteristics, would depend on the molecular interactions and the environment in which it is studied. Overall, this compound's unique structural features suggest potential applications in medicinal chemistry and materials science, although further research would be necessary to fully understand its properties and applications.

Formula: C₁₇H₂₂N₂O

Synonyms:

• 2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]-

EN171

CAS: 2191110-79-7

EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol.

Formula: C₁₇H₂₂N₂O

Color and Shape: Solid

Molecular weight: 270.37

Ref: TM-T200403