CAS 219138-18-8

H-Lys(Abz)-Pro-Pro-pNA

CAS: 219138-18-8

Internally quenched fluorogenic (FRET) substrate which allows aminopeptidase P (APP) activity determination by a continuous fluorescent assay (kcat/Km = 29’000 M⁻¹s⁻¹ for E.coli APP and kcat/Km = 1’142’000 M⁻¹s⁻¹ for rat APP).

Formula: C₂₉H₃₇N₇O₆

Purity: 95.8%

Color and Shape: Light Yellow Lyophilisate

Molecular weight: 579.66

Ref: 01-4027668

H-Lys(Abz)-Pro-Pro-pNA

CAS: 219138-18-8

H-Lys(Abz)-Pro-Pro-pNA is a potent and selective DPP-IV inhibitor that has been shown to be active in humans. This drug binds to the DPP-IV enzyme and prevents it from breaking down the incretin hormone, GLP-1, which is released by the intestine in response to food intake. This leads to increased insulin production and an improved glycemic profile in people with type 2 diabetes. H-Lys(Abz)-Pro-Pro-pNA also inhibits endoproteolysis of dipeptidyl peptidase IV (DPPIV), which reduces its activity against other enzymes such as amyloid beta protein precursor protein (APP) and angiotensin II receptor type 1 (AT1R).

Formula: C₂₉H₃₇N₇O₆

Purity: Min. 95%

Molecular weight: 579.65 g/mol

Ref: 3D-FL110802