CAS 219580-11-7

N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea

Description:

N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea, with CAS number 219580-11-7, is a synthetic organic compound characterized by its complex molecular structure, which includes multiple functional groups such as urea, amine, and aromatic moieties. This compound is typically categorized as a small molecule and may exhibit properties relevant to medicinal chemistry, particularly in the context of drug development. Its structure suggests potential interactions with biological targets, possibly influencing pathways related to cell signaling or proliferation. The presence of diethylamino and dimethylethyl groups may enhance its solubility and bioavailability. Additionally, the compound's pyrimidine and pyridine rings indicate potential for aromatic interactions, which can be crucial for binding affinity in biological systems. As with many synthetic compounds, its stability, reactivity, and pharmacokinetic properties would need to be evaluated through experimental studies to determine its suitability for therapeutic applications.

Formula: C₂₈H₄₁N₇O₃

InChI: InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)

InChI key: InChIKey=DXCUKNQANPLTEJ-UHFFFAOYSA-N

SMILES: N(C(NC(C)(C)C)=O)C=1C(=CC2=C(N1)N=C(NCCCCN(CC)CC)N=C2)C3=CC(OC)=CC(OC)=C3

Synonyms:

• 1-tert-Butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
• N-[2-[[4-(Diethylamino)Butyl]Amino-6-(3,5-Dimethoxyphenyl)Pyrido[2,3-D]Pyrimidin-7-Yl]-N'-(1,1-Dimethylethyl)Urea
• Pd 173074
• Pd173074
• Urea, N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-

PD 173074

CAS: 219580-11-7

Formula: C₂₈H₄₁N₇O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 523.6702

Ref: IN-DA00BEAR

PD 173074

CAS: 219580-11-7

PD 173074

Purity: 99%

Color and Shape: Yellow Crystals

Molecular weight: 523.67g/mol

Ref: 54-BIFK0034

PD 173074

CAS: 219580-11-7

Formula: C₂₈H₄₁N₇O₃

Molecular weight: 523.67

Ref: 7W-GK2281

PD173074

CAS: 219580-11-7

PD173074

Purity: ≥95%

Molecular weight: 523.67g/mol

Ref: 54-BUP15494

PD 173074

CAS: 219580-11-7

Formula: C₂₈H₄₁N₇O₃

Purity: >95.0%(HPLC)

Color and Shape: White to Yellow to Orange powder to crystal

Molecular weight: 523.68

Ref: 3B-P2474

PD173074

CAS: 219580-11-7

PD173074 inhibits FGFR1 (IC50: 25 nM) and VEGFR2 (100-200 nM); ~1000x more selective for FGFR1 over PDGFR/c-Src.

Formula: C₂₈H₄₁N₇O₃

Purity: 98.15% - 98.21%

Color and Shape: Yellow Solid

Molecular weight: 523.67

Ref: TM-T2642

PD 173074

CAS: 219580-11-7

Formula: C₂₈H₄₁N₇O₃

Molecular weight: 523.68

Ref: 4Z-PF-0006

PD-173074

Controlled Product

CAS: 219580-11-7

Applications PD 173074 is a selective FGFR1 and FGFR3 inhibitor. PD 173074 is a compound induced a dose-dependent reduce in cell viability and an increase in apoptosis, accompanied by a decrease in extracellular signal-related kinase phosphorylation.
References Mohammadi, M., et al.: Science, 276, 955 (1997), Yagasaki, F., et al.: Cancer Res., 61, 8371 (2001), Keats, J., et al.: Blood, 101, 1520 (2003), Buchler, et al.: 9, 119 (2007),

Formula: C₂₈H₄₁N₇O₃

Color and Shape: Neat

Molecular weight: 523.67

Ref: TR-P217700

PD 173074

CAS: 219580-11-7

Inhibitor of FGFR1 receptor tyrosine kinase

Formula: C₂₈H₄₁N₇O₃

Purity: Min. 95%

Molecular weight: 523.67 g/mol

Ref: 3D-BP162784