Peptaibolin is a peptide antibiotic characterized by its unique structure and biological activity. It is composed of a sequence of amino acids that typically includes non-standard amino acids, contributing to its stability and function. This compound is known for its antimicrobial properties, particularly against certain bacteria and fungi, making it of interest in pharmaceutical and agricultural applications. Peptaibolin exhibits a helical conformation, which is crucial for its interaction with biological membranes, leading to membrane disruption in target organisms. Its mechanism of action often involves the formation of pores in the cell membrane, resulting in cell lysis. Additionally, peptaibolin's synthesis can be achieved through various methods, including solid-phase peptide synthesis, allowing for modifications that can enhance its efficacy or reduce toxicity. Overall, peptaibolin represents a significant area of study in the development of new antimicrobial agents, particularly in the face of rising antibiotic resistance.

peptaibolin

219637-06-6: Peptaibolin is a peptide antibiotic characterized by its unique structure and biological activity. It is composed of a sequence of amino acids that typically includes non-standard amino acids, contributing to its stability and function. This compound is known for its antimicrobial properties, particularly against certain bacteria and fungi, making it of interest in pharmaceutical and agricultural applications. Peptaibolin exhibits a helical conformation, which is crucial for its interaction with biological membranes, leading to membrane disruption in target organisms. Its mechanism of action often involves the formation of pores in the cell membrane, resulting in cell lysis. Additionally, peptaibolin's synthesis can be achieved through various methods, including solid-phase peptide synthesis, allowing for modifications that can enhance its efficacy or reduce toxicity. Overall, peptaibolin represents a significant area of study in the development of new antimicrobial agents, particularly in the face of rising antibiotic resistance.

<p>Peptaibolin exhibits activity against Gram-positive bacteria and yeast. The minimum inhibitory concentration (MIC) for its effect on Bacillus subtilis [ATCC 6633] and Candida albicans is 100 μg/mL.</p>

CAS 219637-06-6

peptaibolin

Peptaibolin

Ref: TM-TN10857