CAS 219680-11-2

Zabofloxacin

Description:

Zabofloxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity, particularly against Gram-negative and some Gram-positive bacteria. It operates by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication and transcription. This mechanism disrupts bacterial cell division and growth. Zabofloxacin is notable for its improved pharmacokinetic properties, which enhance its efficacy and reduce the likelihood of resistance development compared to older fluoroquinolones. It is typically administered orally and has been studied for its potential use in treating various infections, including respiratory and urinary tract infections. The compound's chemical structure includes a bicyclic core, which is common among fluoroquinolones, and it features various substituents that contribute to its antibacterial potency and pharmacological profile. As with other antibiotics, careful consideration of its use is essential to mitigate the risk of resistance and ensure effective treatment outcomes.

Formula: C₁₉H₂₀FN₅O₄

InChI: InChI=1S/C19H20FN5O4/c1-29-23-14-6-24(9-19(14)7-21-8-19)17-13(20)4-11-15(26)12(18(27)28)5-25(10-2-3-10)16(11)22-17/h4-5,10,21H,2-3,6-9H2,1H3,(H,27,28)

InChI key: InChIKey=ZNPOCLHDJCAZAH-UHFFFAOYSA-N

SMILES: N(OC)=C1C2(CN(C1)C=3N=C4N(C=C(C(O)=O)C(=O)C4=CC3F)C5CC5)CNC2

Synonyms:

• 1,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[8-(methoxyimino)-2,6-diazaspiro[3.4]oct-6-yl]-4-oxo-
• 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[8-(methoxyimino)-2,6-diazaspiro[3.4]oct-6-yl]-4-oxo-1,8-naphthyridine-3-carboxylic acid
• Zabofloxacin

Zabofloxacin

CAS: 219680-11-2

Zabofloxacin is a synthetic fluoroquinolone antibiotic, which is derived from chemical synthesis with a distinct bactericidal mode of action. Its mechanism involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication, transcription, and repair. This dual targeting results in potent antibacterial activity against a wide range of Gram-positive and Gram-negative pathogens.

Formula: C₁₉H₂₀FN₅O₄

Purity: Min. 95%

Molecular weight: 401.4 g/mol

Ref: 3D-UIA68011

Zabofloxacin

CAS: 219680-11-2

Zabofloxacin inhibits bacterial topoisomerases II/IV, effectively targeting gram-positive pathogens like S. aureus and S. pneumoniae.

Formula: C₁₉H₂₀FN₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 401.39

Ref: TM-T13406