CAS 219923-05-4

N-Acetylcolchinol phosphate

Description:

N-Acetylcolchinol phosphate, identified by its CAS number 219923-05-4, is a chemical compound that belongs to the class of phosphates. It is derived from colchicine, a natural alkaloid known for its use in treating gout and certain types of cancer. The compound features an acetyl group attached to the colchicine structure, which may influence its biological activity and solubility. N-Acetylcolchinol phosphate is characterized by its phosphate group, which can enhance its reactivity and potential interactions in biochemical pathways. This compound may exhibit properties such as being a substrate or inhibitor in enzymatic reactions, depending on its specific interactions with biological molecules. Its synthesis and application are of interest in medicinal chemistry, particularly in the development of therapeutic agents. However, detailed studies on its pharmacokinetics, toxicity, and efficacy are essential for understanding its potential uses in clinical settings. As with many chemical substances, safety data and handling precautions should be observed when working with N-Acetylcolchinol phosphate.

Formula: C₂₀H₂₄NO₈P

InChI: InChI=1S/C20H24NO8P/c1-11(22)21-16-8-5-12-9-17(26-2)19(27-3)20(28-4)18(12)14-7-6-13(10-15(14)16)29-30(23,24)25/h6-7,9-10,16H,5,8H2,1-4H3,(H,21,22)(H2,23,24,25)/t16-/m0/s1

InChI key: InChIKey=UGBMEXLBFDAOGL-INIZCTEOSA-N

SMILES: O(C)C1=C2C=3C([C@@H](NC(C)=O)CCC2=CC(OC)=C1OC)=CC(OP(=O)(O)O)=CC3

Synonyms:

• ZM 445526
• N-[(5S)-6,7-Dihydro-9,10,11-trimethoxy-3-(phosphonooxy)-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide
• ZD 6126
• Acetamide, N-[(5S)-6,7-dihydro-9,10,11-trimethoxy-3-(phosphonooxy)-5H-dibenzo[a,c]cyclohepten-5-yl]-
• N-Acetylcolchicinol dihydrogen phosphate

AZD-6126

CAS: 219923-05-4

AZD6126 (ANG-453), a water-soluble prodrug converted to N-acetylcolchinol in vivo, potentially treats solid tumors by inhibiting angiogenesis and tubulin.

Formula: C₂₀H₂₄NO₈P

Color and Shape: Solid

Molecular weight: 437.38

Ref: TM-T69813