CAS 219989-84-1

Ixabepilone

Description:

Ixabepilone is a synthetic epothilone, a class of compounds that function as microtubule stabilizers, similar to taxanes. It is primarily used in the treatment of metastatic breast cancer, particularly in cases where other therapies have failed. The chemical formula of ixabepilone is C22H27N3O4S, and it has a molecular weight of approximately 429.54 g/mol. This compound exhibits a unique mechanism of action by binding to the β-tubulin subunit of microtubules, thereby inhibiting their depolymerization and disrupting normal mitotic processes in cancer cells. Ixabepilone is characterized by its ability to overcome resistance mechanisms that often limit the effectiveness of traditional chemotherapeutic agents. It is administered intravenously and has a relatively long half-life, allowing for less frequent dosing. Side effects may include peripheral neuropathy, myelosuppression, and gastrointestinal disturbances. Overall, ixabepilone represents an important therapeutic option in oncology, particularly for patients with resistant forms of breast cancer.

Formula: C₂₇H₄₂N₂O₅S

InChI: InChI=1/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1

InChI key: InChIKey=FABUFPQFXZVHFB-PVYNADRNSA-N

SMILES: C[C@@]12[C@@](O1)(C[C@@H](\C(=C\C=3N=C(C)SC3)\C)NC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC2)[H]

Synonyms:

• (1R,5S,6S,7R,10S,14S,16S)-6,10-Dihydroxy-1,5,7,9,9-pentamethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14.1.0]heptadecane-8,12-dione
• (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
• (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
• 17-Oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1S,3S,7S,10R,11S,12S,16R)-
• Azaepothilone B
• Bms 247550
• Bms 247550-1
• Ixempra
• Ixabepilone, Free Base, >99%
• Ixabepilone Q: What is the CAS Number of
• CS-1169
• IxabepiloneQ: What is
• Azi-epothilone B
• IXABEPILONE
• Unii-K27005np0a
• Ixabepilone Q: What is the storage condition of
• ixabepilone 219989-84-1
• Ixabepilone
• Aza-epothilone B
• Ixempra kit
• Ixabepilone Q: What are the applications of
• Ixabepilone BMS-247550
• Ixabepilone (Azaepothilone B

Ixabepilone

CAS: 219989-84-1

Antibiotics nesoi

Formula: C₂₇H₄₂N₂O₅S

Color and Shape: White Off-White Powder

Molecular weight: 506.28144

Ref: 45-1354400

Ixabepilone

CAS: 219989-84-1

Formula: C₂₇H₄₂N₂O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 506.6978

Ref: IN-DA00BE7K

Ixabepilone

CAS: 219989-84-1

Ixabepilone

Purity: 98%

Molecular weight: 506.7g/mol

Ref: 54-OR1023268

Ixabepilone

CAS: 219989-84-1

Ixabepilone

Purity: ≥98%

Molecular weight: 506.7g/mol

Ref: 54-BUP07718

Ixabepilone

CAS: 219989-84-1

Formula: C₂₇H₄₂N₂O₅S

Molecular weight: 506.70

Ref: 7W-GP7590

Ixabepilone

CAS: 219989-84-1

Formula: C₂₇H₄₂N₂O₅S

Color and Shape: White To Off-White Solid

Molecular weight: 506.71

Ref: 4Z-I-069001

Ixabepilone

CAS: 219989-84-1

Ixabepilone (Azaepothilone B) is an orally bioavailable microtubule inhibitor.

Formula: C₂₇H₄₂N₂O₅S

Purity: 98% - 99.50%

Color and Shape: Solid

Molecular weight: 506.7

Ref: TM-T6864

Ixabepilone-13C2,15N

CAS: 219989-84-1

Formula: C₂₅₁₃C₂H₄₂N₁₅NO₅S

Molecular weight: 509.68

Ref: 4Z-I-069009

Ixabepilone

Controlled Product

CAS: 219989-84-1

Applications Ixabepilone is an anti-tumor agent used in the treatment of patients suffering from solid tumors, such as metastatic breast cancer.
References Duska, L. et al.: Gynecol. Oncol., 135, 44 (2014); Deeken, J. et al.: Cancer Chemother. Pharmacol., 73, 1071 (2014);

Formula: C₂₇H₄₂N₂O₅S

Color and Shape: Neat

Molecular weight: 506.70

Ref: TR-I941990

Ixabepilone-13C2,15N

Controlled Product

CAS: 219989-84-1

Formula: C₂C₂₅H₄₂₁₅NNO₅S

Color and Shape: Neat

Molecular weight: 509.676

Ref: TR-I941992

Ixabepilone

CAS: 219989-84-1

Microtubule-stabilizing agent; antineoplastic;

Formula: C₂₇H₄₂N₂O₅S

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 506.71 g/mol

Ref: 3D-FD45423