CAS 219989-84-1: Ixabepilone

Description: Ixabepilone is a synthetic epothilone, a class of compounds that function as microtubule stabilizers, similar to taxanes. It is primarily used in the treatment of metastatic breast cancer, particularly in cases where other therapies have failed. The chemical formula of ixabepilone is C22H27N3O4S, and it has a molecular weight of approximately 429.54 g/mol. This compound exhibits a unique mechanism of action by binding to the β-tubulin subunit of microtubules, thereby inhibiting their depolymerization and disrupting normal mitotic processes in cancer cells. Ixabepilone is characterized by its ability to overcome resistance mechanisms that often limit the effectiveness of traditional chemotherapeutic agents. It is administered intravenously and has a relatively long half-life, allowing for less frequent dosing. Side effects may include peripheral neuropathy, myelosuppression, and gastrointestinal disturbances. Overall, ixabepilone represents an important therapeutic option in oncology, particularly for patients with resistant forms of breast cancer.

Formula: C₂₇H₄₂N₂O₅S

InChI: InChI=1S/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1

InChI key: InChIKey=FABUFPQFXZVHFB-PVYNADRNSA-N

SMILES: O=C1NC(C(=CC=2N=C(SC2)C)C)CC3OC3(C)CCCC(C)C(O)C(C(=O)C(C)(C)C(O)C1)C

Synonyms:

• (1R,5S,6S,7R,10S,14S,16S)-6,10-Dihydroxy-1,5,7,9,9-pentamethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14.1.0]heptadecane-8,12-dione
• (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
• (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
• 17-Oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1S,3S,7S,10R,11S,12S,16R)-
• Azaepothilone B
• Bms 247550
• Bms 247550-1
• Ixempra

Ixabepilone

CAS: 219989-84-1

Antibiotics nesoi

• Formula: C₂₇H₄₂N₂O₅S
• Color and Shape: White Off-White Powder
• Molecular weight: 506.28144

IXABEPILONE

CAS: 219989-84-1

• Formula: C₂₇H₄₂N₂O₅S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 506.6978

Ixabepilone

CAS: 219989-84-1

• Formula: C₂₇H₄₂N₂O₅S
• Molecular weight: 506.70

Ixabepilone

CAS: 219989-84-1

• Formula: C₂₇H₄₂N₂O₅S
• Color and Shape: White To Off-White Solid
• Molecular weight: 506.71

Ixabepilone-13C2,15N

CAS: 219989-84-1

• Formula: C₂₅₁₃C₂H₄₂N₁₅NO₅S
• Molecular weight: 509.68

Ixabepilone

CAS: 219989-84-1

Ixabepilone (Azaepothilone B) is an orally bioavailable microtubule inhibitor.

• Formula: C₂₇H₄₂N₂O₅S
• Purity: 98% - 98.60%
• Color and Shape: Solid
• Molecular weight: 506.7

Ixabepilone

CAS: 219989-84-1

Microtubule-stabilizing agent; antineoplastic;

• Formula: C₂₇H₄₂N₂O₅S
• Purity: Min. 95 Area-%
• Color and Shape: White Powder
• Molecular weight: 506.71 g/mol

Ixabepilone

CAS: 219989-84-1

Applications Ixabepilone is an anti-tumor agent used in the treatment of patients suffering from solid …

• Formula: C₂₇H₄₂N₂O₅S
• Color and Shape: Neat
• Molecular weight: 506.70

Ixabepilone-13C2,15N

CAS: 219989-84-1

• Formula: C₂C₂₅H₄₂NNO₅S
• Color and Shape: Neat
• Molecular weight: 509.676