CAS 22003-12-9

2′-Deoxy-5-methylcytidine 5′-(tetrahydrogen triphosphate)

Description:

2′-Deoxy-5-methylcytidine 5′-(tetrahydrogen triphosphate), commonly referred to as d5mCTP, is a nucleotide analog characterized by the presence of a methyl group at the 5-position of the cytidine base. This modification can influence its biological properties, particularly in DNA synthesis and modification. The molecule consists of a deoxyribose sugar, a cytosine base, and a triphosphate group, which is essential for its role in nucleic acid metabolism. The triphosphate moiety provides the energy necessary for incorporation into DNA during replication and transcription processes. d5mCTP is often used in molecular biology applications, such as in the synthesis of modified DNA strands or in studies of DNA methylation patterns. Its CAS number, 22003-12-9, uniquely identifies this compound in chemical databases. The presence of the methyl group can affect the stability and binding affinity of the nucleotide, making it a valuable tool for researchers investigating epigenetic modifications and other biochemical pathways.

Formula: C₁₀H₁₈N₃O₁₃P₃

InChI: InChI=1S/C10H18N3O13P3/c1-5-3-13(10(15)12-9(5)11)8-2-6(14)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,14H,2,4H2,1H3,(H,19,20)(H,21,22)(H2,11,12,15)(H2,16,17,18)/t6-,7+,8+/m0/s1

InChI key: InChIKey=NGYHUCPPLJOZIX-XLPZGREQSA-N

SMILES: O=C1N([C@@H]2O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@@H](O)C2)C=C(C)C(N)=N1

Synonyms:

• Cytidine, 2′-deoxy-5-methyl-, 5′-(tetrahydrogen triphosphate)
• 2′-Deoxy-5-methylcytidine 5′-(tetrahydrogen triphosphate)
• 2′-Deoxy-5-methylcytidine triphosphate
• 5-Methyl-dCTP
• Cytidine 5′-(tetrahydrogen triphosphate), 2′-deoxy-5-methyl-

2'-Deoxy-5-methylcytidine-5'-triphosphate sodium salt - 10 mM aqueous solution

CAS: 22003-12-9

2'-Deoxy-5-methylcytidine-5'-triphosphate sodium salt - 10 mM aqueous solution is an inhibitor of the methyl transferase domain that is found in all DNA methyltransferases. It has been shown to inhibit transcriptional regulation and cellular transformation, as well as to induce DNA damage. The optimum pH for this compound is 7.4 and it hydrolyzes at pH levels lower than 5.0.

Formula: C₁₀H₁₈N₃O₁₃P₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 481.18 g/mol

Ref: 3D-ND71642