CAS 220036-08-8

6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine

Description:

6-(Cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine, with the CAS number 220036-08-8, is a chemical compound that belongs to the class of nitrosopyrimidines. This substance features a pyrimidine ring substituted with a nitroso group and an amine group, which contributes to its reactivity and potential biological activity. The presence of the cyclohexylmethoxy group enhances its lipophilicity, potentially influencing its solubility and permeability in biological systems. The compound may exhibit interesting pharmacological properties, making it a subject of interest in medicinal chemistry. Its structural characteristics suggest that it could participate in various chemical reactions, including nucleophilic substitutions and redox reactions, due to the presence of both electron-donating and electron-withdrawing groups. As with many nitrosated compounds, it is essential to consider safety and handling precautions due to potential toxicity and reactivity. Further studies would be necessary to fully elucidate its properties, mechanisms of action, and potential applications in pharmaceuticals or other fields.

Formula: C₁₁H₁₇N₅O₂

InChI: InChI=1/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)

SMILES: C1CCC(CC1)COc1c(c(N)[nH]c(=N)n1)N=O

Synonyms:

• Nu6027

Nu 6027

CAS: 220036-08-8

Formula: C₁₁H₁₇N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 251.2850

Ref: IN-DA00C37J

NU6027

CAS: 220036-08-8

NU6027

Purity: ≥98%

Molecular weight: 251.29g/mol

Ref: 54-BUP13415

NU6027

CAS: 220036-08-8

Formula: C₁₁H₁₇N₅O₂

Molecular weight: 251.28

Ref: 7W-GK7791

NU6027

CAS: 220036-08-8

NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-

Formula: C₁₁H₁₇N₅O₂

Purity: 98.36%

Color and Shape: Solid

Molecular weight: 251.29

Ref: TM-T6612

NU6027

CAS: 220036-08-8

Purity: ≥98%

Molecular weight: 251.2899933

Ref: 10-F870351

NU6027

Controlled Product

CAS: 220036-08-8

Applications NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors
References Arris, C.E., et. al.: J. Med. Che., 43, 2797 (2000); Peasland, A., et. al.: Brit. J. Cancer, 105, 372 (2011)

Formula: C₁₁H₁₇N₅O₂

Color and Shape: Neat

Molecular weight: 251.285

Ref: TR-N925280

NU6027

CAS: 220036-08-8

NU6027 is a potent checkpoint kinase 1 (CHK1) inhibitor, which is synthesized as a small molecule compound designed to interfere with specific biochemical pathways in cellular biology. The source of this compound lies in synthetic organic chemistry, where it was developed to target and inhibit the activity of CHK1 kinase. This enzyme is pivotal in the cell cycle, particularly in the DNA damage response pathway. By inhibiting CHK1, NU6027 disrupts the cell's ability to manage DNA damage and repair processes, thereby promoting cell cycle arrest and apoptosis in selectively targeted cells.

Formula: C₁₁H₁₇N₅O₂

Purity: Min. 95%

Molecular weight: 251.28 g/mol

Ref: 3D-VIA03608