CAS 220119-17-5

Selamectin

Description:

Selamectin is a semi-synthetic derivative of avermectin, primarily used as an antiparasitic agent in veterinary medicine. It is effective against a variety of external and internal parasites, including fleas, ticks, and certain types of worms in dogs and cats. Selamectin functions by binding to glutamate-gated chloride channels in the nervous system of parasites, leading to paralysis and death. The substance is typically administered topically, allowing for sustained release and prolonged efficacy. Selamectin is characterized by its high lipophilicity, which aids in its absorption through the skin and distribution in the body. It has a relatively low toxicity profile in mammals, making it safe for use in pets when applied as directed. Additionally, Selamectin is stable under normal storage conditions and has a long shelf life, contributing to its practicality as a veterinary treatment. Its effectiveness and safety profile have made it a popular choice for managing parasitic infections in companion animals.

Formula: C₄₃H₆₃NO₁₁

InChI: InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1

InChI key: InChIKey=AFJYYKSVHJGXSN-XHKIUTQPSA-N

SMILES: O[C@@]1/2[C@]3(/C(=N\O)/C(C)=C[C@]1(C(=O)O[C@@]4(C[C@@]5(O[C@@]([C@@H](C)CC5)(C6CCCCC6)[H])O[C@@](C4)(C/C=C(\C)/[C@@H](O[C@H]7C[C@H](OC)[C@@H](O)[C@H](C)O7)[C@@H](C)\C=C\C=C2/CO3)[H])[H])[H])[H]

Synonyms:

• (2aE,4E,5'S,6S,6'S,7S,8E,11R,13R,15S,17aR,20Z,20aR,20bS)-6'-cyclohexyl-20b-hydroxy-20-(hydroxyimino)-5',6,8,19-tetramethyl-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl (4ξ)-2,6-dideoxy-3-O-methyl-L-threo-hexopyranoside
• (2aE,4E,5'S,6S,6'S,7S,8E,11R,13R,15S,17aR,20aR,20bS)-6'-cyclohexyl-7-((2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy)-3',4',5',6,6',7,10,11,14,15,20a,20b-dodecahydro-20b-hydroxy-5',6,8,19-tetramethylspiro(11,15-methano-2H,13H,17H-furo(4,3,2-pq)(2,6)benzodioxacyclooctadecin-13,2'-(2H)pyran)-17,20(17aH)-dione 20-oxime
• (5'S,6S,6'S,7S,11R,13R,15S,17aR,20Z,20aR,20bS)-6'-cyclohexyl-20b-hydroxy-20-(hydroxyimino)-5',6,8,19-tetramethyl-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranoside
• (5Z)-25-Cyclohexyl-4′-O-de(2,6-dideoxy-3-O-methyl-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A_1a
• 25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-avermectin A1a
• 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22 23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide
• Avermectin A1a, 25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-
• Avermectin A1a,25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-,(5Z)-
• Avermectin A_1a, 25-cyclohexyl-4′-O-de(2,6-dideoxy-3-O-methyl-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-, (5Z)-
• Chanhold
• Evicto
• Revolution
• Revolution (antibiotic)
• Selamectin
• Selamectin [USAN:INN]
• Selarid
• Stronghold
• Uk-124,114
• Unii-A2669Owx9N

Selamectin

CAS: 220119-17-5

Formula: C₄₃H₆₃NO₁₁

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 769.97

Ref: 3B-E1500

SELAMECTIN FOR PEAK IDENTIFICATION CRS

CAS: 220119-17-5

SELAMECTIN FOR PEAK IDENTIFICATION CRS

Formula: C₄₃H₆₃NO₁₁

Color and Shape: Powder.

Molecular weight: 769.9604

Ref: 41-Y0001734

Selamectin

CAS: 220119-17-5

Lactones, nesoi

Formula: C₄₃H₆₃NO₁₁

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 769.44011

Ref: 45-1611729

Selamectin

CAS: 220119-17-5

Formula: C₄₃H₆₃NO₁₁

Purity: 95%

Color and Shape: Solid

Molecular weight: 769.9604

Ref: IN-DA00BBNQ

Selamectin

CAS: 220119-17-5

Selamectin

Purity: ≥98%

Molecular weight: 769.96g/mol

Ref: 54-BUP15413

Selamectin

CAS: 220119-17-5

Selamectin

Purity: 95%

Molecular weight: 769.96g/mol

Ref: 54-OR1025007

Selamectin

CAS: 220119-17-5

Formula: C₄₃H₆₃NO₁₁

Color and Shape: White To Off-White Solid

Molecular weight: 769.98

Ref: 4Z-S-064001

Selamectin 100 µg/mL in Acetonitrile

CAS: 220119-17-5

Formula: C₄₃H₆₃NO₁₁

Color and Shape: Single Solution

Molecular weight: 769.96

Ref: 04-A16931500AL-100

Selamectin

Controlled Product

CAS: 220119-17-5

Formula: C₄₃H₆₃NO₁₁

Color and Shape: Neat

Molecular weight: 769.96

Ref: 04-C16931500

Selamectin

CAS: 220119-17-5

Ref: 7W-GW6519

Selamectin

CAS: 220119-17-5

Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in

Formula: C₄₃H₆₃NO₁₁

Purity: 99.84%

Color and Shape: Solid

Molecular weight: 769.96

Ref: TM-T4059

Selamectin

CAS: 220119-17-5

Purity: ≥97%

Molecular weight: 769.9730225

Ref: 10-F951524

Selamectin

Controlled Product

CAS: 220119-17-5

Applications Selamectin is a topical parasiticide and also used as a veterinary antihelminithic agent on animals.
References Eshar, D., et al.: J. Am. Veterin. Med. Association., 241, 1056 (2012); Geis-Asteggiante, L., et al.: J. Chromatograph., 1258, 43 (2012);

Formula: C₄₃H₆₃NO₁₁

Color and Shape: Neat

Molecular weight: 769.96

Ref: TR-S247990