CAS 220141-70-8

5-Fluoroorotic acid monohydrate

Description:

5-Fluoroorotic acid monohydrate is a chemical compound that serves as a derivative of orotic acid, characterized by the substitution of a fluorine atom at the 5-position of the pyrimidine ring. This modification imparts unique properties, making it of interest in various biochemical and pharmaceutical applications. The monohydrate form indicates the presence of one molecule of water associated with each molecule of the acid, which can influence its solubility and stability. Typically, 5-fluoroorotic acid exhibits moderate solubility in water and is often utilized in research related to nucleic acid metabolism and as a potential therapeutic agent in cancer treatment due to its ability to interfere with pyrimidine metabolism. Its mechanism of action may involve the inhibition of specific enzymes involved in nucleotide synthesis. As with many fluorinated compounds, it may also exhibit distinct biological activities and toxicity profiles, necessitating careful handling and study in laboratory settings. Overall, 5-fluoroorotic acid monohydrate is a compound of significant interest in medicinal chemistry and biochemistry.

Formula: C₅H₃FN₂O₄H₂O

5-Fluoroorotic Acid Monohydrate

CAS: 220141-70-8, 703-95-7

Formula: C₅H₃FN₂O₄·H₂O

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 192.11

Ref: 3B-F0382

5-FLUOROOROTIC ACID HYDRATE 98

CAS: 220141-70-8

Formula: C₅H₅FN₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 192.1020

Ref: IN-DA00BBOY

5-Fluoroorotic acid monohydrate

CAS: 220141-70-8

5-Fluoroorotic acid monohydrate

Formula: C₅H₃FN₂O₄·H₂O

Purity: 97%

Color and Shape: faint yellow crystalline powder

Molecular weight: 192.10g/mol

Ref: 54-PC4054

5-Fluoroorotic Acid Monohydrate (Ultra Pure)

CAS: 220141-70-8

Applications 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in m
References Winston, F., et al.: Genetics, 107, 179 (1984); Boeke, J.D., et al.: Methods Enzymol., 154, 164 (1987); Rathod, P.K., et al.: Antimicrob. Agents Chemother., 33, 1090 (1989); Rathod, P.K., et al.: Antimicrob. Agents Chemother., 36, 704 (1992); Gomez, Z.M . and Rathod, P.K.: Antimicrob. Agents Chemother., 34, 1371 (1990); Gassis, S. and Rathod, P.K.: Antimicrob. Agents Chemother., 40, 914 (1996)

Formula: C₅H₅FN₂O₅

Color and Shape: White Solid

Molecular weight: 192.10

Ref: TR-F595000

5-Fluoroorotic Acid Monohydrate (5-FOA Monohydrate) for molecular biology, 98%

CAS: 220141-70-8

Formula: C₅H₃FN₂O₄·H₂O

Purity: min. 98%

Color and Shape: Off white to pale yellow, Powder

Molecular weight: 192.10

Ref: SR-11933

5-Fluoroorotic acid, monohydrate

CAS: 220141-70-8

Formula: C₅H₅FN₂O₅

Purity: 97%

Color and Shape: Solid, Crystalline Powder or Powder

Molecular weight: 192.102

Ref: 10-F003234

5-Fluoroorotic acid monohydrate

CAS: 220141-70-8

5-Fluoroorotic acid (monohydrate) (5-Fluorouracil-6-carboxylic acid Mono(hydrate); 5-FOA) is employed to detect the expression of the URA3 gene in yeast molecular genetic constructs. Yeast possessing an active URA3 gene (which encodes orotidine-5'-monophosphate decarboxylase) convert 5-FOA into 5-fluorodeoxyuridine, a substance toxic to cells. Yeast strains with mutations in the URA3 gene that confer resistance can grow in the presence of 5-FOA if uracil is added to the medium.

Formula: C₅H₅FN₂O₅

Color and Shape: Solid

Molecular weight: 192.10

Ref: TM-T200989