CAS 22033-87-0

Olesoxime

Description:

Olesoxime, with the CAS number 22033-87-0, is a synthetic organic compound that belongs to the class of oximes. It is primarily recognized for its neuroprotective properties and has been investigated for potential therapeutic applications in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Olesoxime is characterized by its ability to modulate mitochondrial function and promote neuronal survival, which is crucial in conditions where neuronal loss occurs. The compound exhibits a lipophilic nature, allowing it to cross the blood-brain barrier effectively. Its chemical structure features a hydroxylamine functional group, contributing to its reactivity and biological activity. Olesoxime has been studied in various preclinical and clinical settings, demonstrating a favorable safety profile and potential efficacy in enhancing motor function and overall neurological health. As research continues, olesoxime remains a compound of interest in the field of neuropharmacology, with ongoing investigations into its mechanisms of action and broader therapeutic applications.

Formula: C₂₇H₄₅NO

InChI: InChI=1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/t19-,22+,23-,24+,25+,26+,27-/m1/s1

InChI key: InChIKey=QNTASHOAVRSLMD-GYKMGIIDSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=NO)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H]

Synonyms:

• (3E)-cholest-4-en-3-one oxime
• Cholest-4-en-3-one oxime
• NSC 21311
• Tro 19622
• Olesoxime
• (NE)-N-[10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,6,7,8,9,11,12,14,1 5,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]hydroxylamine
• Cholest-4-en-3-one, oxime, NSC 21311

TRO 19622

CAS: 22033-87-0

Formula: C₂₇H₄₅NO

Purity: 98%

Color and Shape: Solid

Molecular weight: 399.6523

Ref: IN-DA007Q60

TRO 19622

CAS: 22033-87-0

Formula: C₂₇H₄₅NO

Purity: ≥ 98.0%

Color and Shape: White solid

Molecular weight: 399.65

Ref: 7W-GK1071

Olesoxime

CAS: 22033-87-0

Olesoxime

Purity: ≥98%

Molecular weight: 399.65g/mol

Ref: 54-BUP05824

TRO 19622

CAS: 22033-87-0

Formula: C₂₇H₄₅NO

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 399.66

Ref: 3B-T4208

Olesoxime

CAS: 22033-87-0

Olesoxime (TRO 19622) (TRO19622), A Mitochondrial-Targeted Neuroprotective Compound,is an experimental neuroprotective drug.

Formula: C₂₇H₄₅NO

Purity: 99.86%

Color and Shape: Solid

Molecular weight: 399.65

Ref: TM-T7629

Olesoxime

Controlled Product

CAS: 22033-87-0

Olesoxime is a drug that has been shown to prevent neuronal death in the cerebrotendinous xanthomatosis (CTX) mouse model. It promotes the production of neurotrophic factors and prevents neuronal death by maintaining ATP levels, mitochondrial membrane potential, and antioxidant defenses. Olesoxime may also be a promising treatment for diabetic neuropathy, as it can alleviate both pain and symptoms of autonomic dysfunction. This drug has also been shown to have antidiabetic effects, improving glucose metabolism and preventing insulin resistance in animal models. Olesoxime is currently being evaluated in Phase II clinical trials for the treatment of CTX.

Formula: C₂₇H₄₅NO

Purity: Min. 95%

Molecular weight: 399.65 g/mol

Ref: 3D-XAA03387