CAS 220352-36-3

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

Description:

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid is a chiral cyclopropane derivative characterized by its unique structural features, including a cyclopropane ring and a carboxylic acid functional group. The presence of the 3,4-difluorophenyl substituent introduces significant electronic and steric effects, which can influence the compound's reactivity and interactions. This compound is typically used in pharmaceutical research and development due to its potential biological activity, particularly in the context of drug design. The specific stereochemistry indicated by the (1R,2R) configuration suggests that it may exhibit distinct pharmacological properties compared to its enantiomers. Additionally, the presence of fluorine atoms can enhance lipophilicity and metabolic stability, making it an interesting candidate for further investigation in medicinal chemistry. Overall, (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid exemplifies the importance of structural modifications in optimizing the efficacy and safety profiles of therapeutic agents.

Formula: C₁₀H₈F₂O₂

Synonyms:

• (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid

(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid

CAS: 220352-36-3

Formula: C₁₀H₈F₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 198.1661

Ref: IN-DA003A4L

Ticagrelor Related Compound 28

CAS: 220352-36-3

Formula: C₁₀H₈F₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 198.17

Ref: 4Z-T-8143

(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid

CAS: 220352-36-3

(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid

Purity: 97%

Molecular weight: 198.17g/mol

Ref: 54-PC421187

Ticagrelor Impurity 134

CAS: 220352-36-3

Formula: C₁₀H₈F₂O₂

Molecular weight: 198.17

Ref: ST-EA-CP-T21035

(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylic Acid

CAS: 220352-36-3

(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylic Acid is a chiral compound that has been shown to be effective in the treatment of acute coronary syndromes. It is an acrylic acid derivative with a cyclopropanecarboxylic acid moiety. This compound has been shown to be effective in the optimization of biocatalytic processes due to its ability to chelate metal ions and stabilize enzymes. (1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylic Acid has also been shown to inhibit malonate decarboxylase and succinate dehydrogenase, which are enzymes that catalyze reactions in the citric acid cycle.

Formula: C₁₀H₈F₂O₂

Purity: Min. 95%

Molecular weight: 198.17 g/mol

Ref: 3D-FD159599

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

CAS: 220352-36-3

Purity: 97%

Molecular weight: 198.1690063

Ref: 10-F789374

(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylic Acid

Controlled Product

CAS: 220352-36-3

Applications (1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylic Acid is an intermediate used to prepare AZD6140 as an orally active reversible P2Y12 receptor antagonist for prevention of thrombosis. It is also used to synthesize triazolopyrimidine derivatives as P2T receptor antagonists.
References Springthorpe, B., et al.: Bioorg. Med. Chem. Lett., 17, 6013 (2007); Guile, S., et al.: PCT Int. Appl., WO 9905143 A1 19990204 (1999)

Formula: C₁₀H₈F₂O₂

Color and Shape: Neat

Molecular weight: 198.17

Ref: TR-D447015