CAS 220497-98-3

Fmoc-D-propargylglycine

Description:

Fmoc-D-propargylglycine is a synthetic amino acid derivative characterized by the presence of a fluorenylmethoxycarbonyl (Fmoc) protecting group and a propargyl functional group. This compound is primarily used in peptide synthesis, particularly in the development of peptides that require specific modifications or functionalities. The Fmoc group serves as a protective moiety for the amino group, allowing for selective deprotection during the synthesis process. The propargyl group introduces an alkyne functionality, which can be utilized in various click chemistry reactions, facilitating the formation of complex molecular structures. Fmoc-D-propargylglycine is typically a white to off-white solid and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). Its unique structural features make it valuable in the fields of medicinal chemistry and bioconjugation, where it can be employed to create diverse peptide libraries or to modify existing peptides for enhanced biological activity. Proper handling and storage conditions are essential to maintain its stability and reactivity.

Formula: C₂₀H₁₇NO₄

Synonyms:

• (R)-2-(Fmoc-amino)-4-pentynoic acid
• (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)pent-4-ynoic acid
• Fmoc-(R)-2-Propargylglycine
• FMOC-D-PRA
• (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-pentynoic acid
• FMOC-D-PROPARGYLGLYCINE
• RARECHEM BK PT 0260
• (R)-N-FMOC-PROPARYLGLYCINE
• (R)-N-FMOC-PROPARGYLGLYCINE
• Fmoc-Propargyl-D-Gly-OH
• FMOC-D-PROPRAGYL-GLY-OH
• FMOC-D-2-PROPARGYLGLYCINE
• (9H-Fluoren-9-yl)MethOxy]Carbonyl D-Pra-OH
• 4-Pentynoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2R)-
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-PROPARGYLGLYCINE
• (R)-2-(Fmoc-amino)-4-pentynoic acid, Fmoc-D-2-propargylglycine
• FMOC-D-PRA-OH
• FMOC-D-GLY(PROPARGYL)-OH
• (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pent-4-ynoic acid
• D-2-Propargylglycine, N-FMOC protected
• (R)-N-FMoc-2-(2'-propynyl)glycine
• fmoc-d-propargyl-gly-oh
• N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-PROPARGYLGLYCINE
• FMoc-D-Propargylglycine FMoc-D-Propargylglycine
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-(R)-2-AMINO-4-PENTYNOIC ACID
• FMOC-D-PROPRAGLYCINE
• Fmoc-D-propraglycine≥ 99% (HPLC)

Fmoc-D-Pra-OH

CAS: 220497-98-3

Building block for the synthesis of precursor peptides for tritiation, and for use in “click chemistry”. D-Pra-containing peptides can be modified or cyclized by 1,3-dipolar cycloaddition, e.g. with alkyl azides. Fmoc-D-Pra-OH can be used for obtaining aryl-modified D-Phe derivatives via rhodium-catalyzed [2+2+2]-cycloaddition.

Formula: C₂₀H₁₇NO₄

Purity: 99.7%

Color and Shape: White Powder

Molecular weight: 335.36

Ref: 01-4072399

Fmoc-D-Pra-OH

CAS: 220497-98-3

Formula: C₂₀H₁₇NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 335.3533

Ref: IN-DA003QN6

Fmoc-D-propargyl-Gly-OH

CAS: 220497-98-3

Molecular weight: 335.35

Ref: 7W-GM6396

D-2-Propargylglycine, N-FMOC protected

CAS: 220497-98-3

D-2-Propargylglycine, N-FMOC protected

Purity: 97%

Ref: 54-OR14677

Fmoc-D-propraglycine

CAS: 220497-98-3

Formula: C₂₀H₁₇NO₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 335.359

Ref: 10-F493076

Fmoc-D-propargylglycine

CAS: 220497-98-3

D-propargylglycine is a chemical compound that belongs to the group of valency modifiers. It is a modulator that can be used in cancer research and as an anti-inflammatory agent. It has been shown to have protein–protein interaction by binding to casein kinase, which may lead to its use in cancer therapy. D-propargylglycine can also interact with other proteins and inflammatory agents, leading to potential applications in the treatment of inflammatory conditions such as arthritis.

Formula: C₂₀H₁₇NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 335.35 g/mol

Ref: 3D-FF40123

Fmoc-D-propargylglycine

Controlled Product

CAS: 220497-98-3

Applications Fmoc-D-propargylglycine

Formula: C₂₀H₁₇NO₄

Color and Shape: Neat

Molecular weight: 335.35

Ref: TR-F657615