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CAS 220578-59-6

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Gemtuzumab ozogamicin

Description:
Gemtuzumab ozogamicin is a monoclonal antibody conjugate used primarily in the treatment of acute myeloid leukemia (AML). It consists of a humanized anti-CD33 antibody linked to a cytotoxic agent, calicheamicin, which is derived from a soil bacterium. The mechanism of action involves the antibody binding to the CD33 antigen, which is expressed on the surface of myeloid cells, facilitating the internalization of the drug and subsequent release of the cytotoxic agent, leading to cell death. Gemtuzumab ozogamicin is characterized by its specificity for CD33-positive cells, making it a targeted therapy that aims to minimize damage to healthy cells. It is administered intravenously and has been associated with various side effects, including infusion-related reactions, myelosuppression, and hepatotoxicity. The drug's approval and use have evolved over time, reflecting ongoing research and clinical trials aimed at optimizing its efficacy and safety profile in treating AML.
Formula:Unspecified
Synonyms:
  • WAY-CMA 676
  • Immunoglobulin G4 (anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 γ4-chain)), disulfide with human-mouse monoclonal hP67.6 κ-chain, dimer, methyl [(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyranosyl]oxy]amino]-β-D-glucopyranosyl]oxy]-13-[2-[[3-[[1-[4-(4-amino-4-oxobutoxy)phenyl]ethylidene]hydrazino]-1,1-dimethyl-3-oxopropyl]dithio]ethylidene]-1-hydroxy-11-oxobicyclo[7.3.1]trideca-4,9-diene-2,6-diyn-10-yl]carbamate conjugate
  • Gemtuzumab ozogamicin
  • CDP 771
  • Immunoglobulin G4 (anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 γ4-chain)), disulfide with human-mouse monoclonal hP67.6 κ-chain, dimer, methyl N-[(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyranosyl]oxy]amino]-β-D-glucopyranosyl]oxy]-13-[2-[[3-[2-[1-[4-(4-amino-4-oxobutoxy)phenyl]ethylidene]hydrazinyl]-1,1-dimethyl-3-oxopropyl]dithio]ethylidene]-1-hydroxy-11-oxobicyclo[7.3.1]trideca-4,9-diene-2,6-diyn-10-yl]carbamate conjugate
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