CAS 22089-22-1

Trofosfamide

Description:

Trofosfamide is a synthetic alkylating agent primarily used in chemotherapy for the treatment of various cancers, particularly in pediatric oncology. It is a derivative of cyclophosphamide and functions by interfering with DNA replication, leading to cell death, particularly in rapidly dividing cancer cells. The compound is characterized by its ability to form DNA cross-links, which inhibit the synthesis of nucleic acids and ultimately disrupt cellular processes. Trofosfamide is typically administered in a prodrug form, requiring metabolic activation to exert its therapeutic effects. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion, with a notable emphasis on its activation in the liver. Side effects may include myelosuppression, gastrointestinal disturbances, and potential long-term risks such as secondary malignancies. Due to its potent effects and associated risks, the use of trofosfamide is carefully monitored in clinical settings, and it is often part of combination therapy regimens to enhance efficacy while managing toxicity.

Formula: C₉H₁₈Cl₃N₂O₂P

InChI: InChI=1S/C9H18Cl3N2O2P/c10-2-6-13-5-1-9-16-17(13,15)14(7-3-11)8-4-12/h1-9H2

InChI key: InChIKey=UMKFEPPTGMDVMI-UHFFFAOYSA-N

SMILES: N(CCCl)(CCCl)P1(=O)N(CCCl)CCCO1

Synonyms:

• 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide
• 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-, 2-oxide
• 3-(2-Chloroethyl)-2-[bis(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorine 2-oxide
• 3-(2-Chloroethyl)-2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
• Asta Z 4828
• Ixoten
• N,N,3-tris(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
• NSC 109723
• Trifosfamide
• Trilofosfamida
• Trilophosphamide
• Triphosphamide
• Trisfosfamide
• Trofosfamid
• Trophosphamid
• Trophosphamide
• Z 4828
• Trofosfamide

Trofosfamide

CAS: 22089-22-1

Formula: C₉H₁₈Cl₃N₂O₂P

Purity: 98%

Color and Shape: Solid

Molecular weight: 323.5842

Ref: IN-DA0037U3

Trofosfamide

CAS: 22089-22-1

Trofosfamide

Purity: ≥98%

Molecular weight: 323.58g/mol

Ref: 54-BUP16395

Trofosfamide

Controlled Product

CAS: 22089-22-1

Applications Antineoplastic; one derivative of cyclophosphamide (NSC-26271).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Potel, J., et al.: Arzneim.-Forsch., 21, 1250 (1971), Bria, E., et al.: Cancer Treat. Rev., 32, 583 (2006), Faivre, S., et al.: J. Clin. Oncol., 24, 25 (2006).

Formula: C₉H₁₈Cl₃N₂O₂P

Color and Shape: Neat

Molecular weight: 323.58

Ref: TR-T892000

Trofosfamide

CAS: 22089-22-1

Trofosfamide is a derivative of oxazaphosphorine with antineoplastic potency.

Formula: C₉H₁₈Cl₃N₂O₂P

Purity: 98.5% - >99.99%

Color and Shape: Solid

Molecular weight: 323.58

Ref: TM-T17172