CAS 221244-14-0

1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Description:

1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, with the CAS number 221244-14-0, is a chemical compound that belongs to the class of pyrazolopyrimidines. This compound features a pyrazolo[3,4-d]pyrimidine core, which is characterized by a fused bicyclic structure that includes both pyrazole and pyrimidine rings. The presence of a 1-naphthalenylmethyl group and a tert-butyl group (1,1-dimethylethyl) contributes to its unique properties, potentially influencing its solubility, stability, and biological activity. Such compounds are often investigated for their pharmacological potential, including roles in medicinal chemistry as kinase inhibitors or in other therapeutic applications. The molecular structure suggests that it may exhibit interesting interactions with biological targets, making it a subject of interest in drug discovery and development. As with many organic compounds, its physical properties, such as melting point, boiling point, and solubility, would need to be determined experimentally for specific applications.

Formula: C₂₀H₂₁N₅

InChI: InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23)

InChI key: InChIKey=GDQXJQSQYMMKRA-UHFFFAOYSA-N

SMILES: C(C)(C)(C)N1C=2C(C(CC=3C4=C(C=CC3)C=CC=C4)=N1)=C(N)N=CN2

Synonyms:

• 1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• 1-Nm-Pp 1
• 1-Nm-Pp1
• 1-Nmpp1
• 1-tert-Butyl-3-(naphthalen-1-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine
• 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-
• PP 1 Analog II

PP1 Analog II, 1NM-PP1

CAS: 221244-14-0

Formula: C₂₀H₂₁N₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 331.4142

Ref: IN-DA007PJB

1-NM-PP1

CAS: 221244-14-0

1-NM-PP1

Purity: ≥98%

Molecular weight: 331.41g/mol

Ref: 54-BUP02666

1-NM-PP1

CAS: 221244-14-0

1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.

Formula: C₂₀H₂₁N₅

Purity: 98% - 98.93%

Color and Shape: White Cyrstalline Solid

Molecular weight: 331.41

Ref: TM-T2153

4-Amino-1-tert-butyl-3-(1’-naphthylmethyl)pyrazolo[3,4-d]pyrimidine

Controlled Product

CAS: 221244-14-0

Applications A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase.
References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999), Davies, S., et al.: Biochem. J., 351, 95 (2000), Regan, J., et al.: J. Med. Chem., 45, 2994 (2002), Bain, J., et al.: Biochem. J., 371, 199 (2003), Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (2005),

Formula: C₂₀H₂₁N₅

Color and Shape: Off White Solid

Molecular weight: 331.41

Ref: TR-A603003

1-NM-PP1

CAS: 221244-14-0

1-NM-PP1, also known as 1NM-PP1, is an inhibitor of the Src kinase. Studies have shown that 1-NM-PP1 inhibits analog-sensitive kinases (as-kinases) characterised by a small amino acid as gatekeeper of the ATP binding site. Tested to prevent parasitic infections, 1-NM-PP1 inhibited the Toxoplasma gondii life cycle when used at a higher concentration than 500 nM.

Formula: C₂₀H₂₁N₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 331.1797

Ref: 3D-FA10330