CAS 221246-12-4

Fandosentan potassium

Description:

Fandosentan potassium is a chemical compound that belongs to the class of endothelin receptor antagonists, specifically targeting the endothelin-1 receptor. It is primarily investigated for its potential therapeutic applications in conditions such as pulmonary arterial hypertension and other cardiovascular diseases. The compound is characterized by its ability to inhibit the action of endothelin-1, a potent vasoconstrictor, thereby promoting vasodilation and improving blood flow. Fandosentan potassium is typically presented as a potassium salt, which enhances its solubility and bioavailability. In terms of its chemical structure, it features specific functional groups that contribute to its receptor-binding affinity and pharmacological activity. The compound has undergone various preclinical and clinical studies to evaluate its efficacy and safety profile. As with many pharmacological agents, understanding its pharmacokinetics, metabolism, and potential side effects is crucial for its development and therapeutic use. Overall, Fandosentan potassium represents a significant area of research in the field of cardiovascular pharmacotherapy.

Formula: C₂₅H₁₈F₃NO₆S·K

InChI: InChI=1S/C25H18F3NO6S.K/c1-2-14-11-15(12-19-23(14)35-13-34-19)21-16-7-3-6-10-20(16)36(32,33)29(22(21)24(30)31)18-9-5-4-8-17(18)25(26,27)28;/h3-12H,2,13H2,1H3,(H,30,31);

InChI key: InChIKey=UGCKPLHQISYRBC-UHFFFAOYSA-N

SMILES: C(O)(=O)C1=C(C=2C(S(=O)(=O)N1C3=C(C(F)(F)F)C=CC=C3)=CC=CC2)C=4C=C5C(=C(CC)C4)OCO5.[K]

Synonyms:

• PD 180988-0016
• 2H-1,2-Benzothiazine-3-carboxylic acid, 4-(7-ethyl-1,3-benzodioxol-5-yl)-2-[2-(trifluoromethyl)phenyl]-, 1,1-dioxide, potassium salt (1:1)
• 2H-1,2-Benzothiazine-3-carboxylic acid, 4-(7-ethyl-1,3-benzodioxol-5-yl)-2-[2-(trifluoromethyl)phenyl]-, 1,1-dioxide, potassium salt
• PD-180988
• potassium 4-(7-ethyl-1,3-benzodioxol-5-yl)-2-[2-(trifluoromethyl)phenyl]-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
• CI-1034
• Fandosentan potassium
• CI 1034

Fandosentan potassium

CAS: 221246-12-4

Fandosentan potassium is a bio-active chemical. Detailed information has not been published.

Formula: C₂₅H₁₈F₃KNO₆S

Color and Shape: Solid

Molecular weight: 556.57

Ref: TM-T31744