CAS 22135-79-1

Naloxone 3-b-D-Glucuronide

Description:

Naloxone 3-b-D-Glucuronide is a metabolite of naloxone, an opioid antagonist used primarily in the treatment of opioid overdose. This compound is characterized by its glucuronide conjugation, which enhances its solubility and alters its pharmacokinetic properties compared to naloxone. The chemical structure includes a naloxone backbone linked to a glucuronic acid moiety, which is responsible for its increased polarity. Naloxone 3-b-D-Glucuronide is generally less pharmacologically active than its parent compound, naloxone, but it can still be detected in biological fluids following naloxone administration. Its presence is often used as a biomarker in pharmacokinetic studies to understand the metabolism and elimination of naloxone in the body. The compound is typically analyzed using techniques such as liquid chromatography coupled with mass spectrometry (LC-MS) for accurate quantification and identification in research and clinical settings. Overall, Naloxone 3-b-D-Glucuronide plays a significant role in the pharmacological profile of naloxone and its therapeutic applications.

Formula: C₂₅H₂₉NO₁₀

Synonyms:

• Naloxone-3-O-β-D-glucuronide
• Naloxone 3--D-Glucuronide
• Naloxone 3-b-D-Glucuronide
• (5a)-4,5-Epoxy-14-hydroxy-6-oxo-17-(2-propenyl)morphinan-3-yl b-D-Glucopyranosiduronic Acid
• Naloxone-3-glucuronid
• (5α)-4,5-Epoxy-14-hydroxy-6-oxo-17-(2-propenyl)Morphinan-3-yl β-D-Glucopyranosiduronic Acid
• (5a)-4,5-Epoxy-14-hydroxy-6-oxo-17-(2-propenyl)morphinan-3-yl -D-Glucopyranosiduronic Acid

Naloxone-3-β-D-glucuronide, 1mg/ml in Methanol/Water : 1/1

Controlled Product

CAS: 22135-79-1

Color and Shape: Single Solution

Ref: LP-NAL-450-HY-1LMH

Naloxone 3-β-D-Glucuronide

CAS: 22135-79-1

Formula: C₂₅H₂₉NO₁₀

Molecular weight: 503.50

Ref: 4Z-N-2134

Naloxone-3-β-D-glucuronide

Controlled Product

CAS: 22135-79-1

Color and Shape: Neat

Ref: LP-NAL-450-HY-10

Naloxone-3-glucuronide

CAS: 22135-79-1

Formula: C₂₅H₂₉NO₁₀

Purity: ≥ 95.0%

Color and Shape: Off-white solid

Molecular weight: 503.50

Ref: 7W-GP0896

Naloxone-d5 3-β-D-Glucuronide

Controlled Product

CAS: 22135-79-1

Applications Naloxone-d5 3-β-D-Glucuronide is a labelled metabolite of Naloxone ((N285000). Narcotic antagonist.
References Scheurer, U., et al.: J. Pharmacol. Exp. Ther., 252, 1324 (1990), Yuan, C., et al.: Clin. Pharmacol. Ther., 59, 469 (1996), Ulens, C., et al.: Biochem. Pharmacol., 62, 1273 (2001), Comert, M., et al.: Eur. J. Pharmacol., 511, 183 (2005),

Formula: C₂₅H₂₄D₅NO₁₀

Color and Shape: Neat

Molecular weight: 508.53

Ref: TR-N285012

Naloxone 3-β-D-Glucuronide

Controlled Product

CAS: 22135-79-1

Stability Hygroscopic
Applications A metabolite of Naloxone. Narcotic antagonist.
References Scheurer, U., et al.: J. Pharmacol. Exp. Ther., 252, 1324 (1990), Yuan, C., et al.: Clin. Pharmacol. Ther., 59, 469 (1996), Ulens, C., et al.: Biochem. Pharmacol., 62, 1273 (2001), Comert, M., et al.: Eur. J. Pharmacol., 511, 183 (2005),

Formula: C₂₅H₂₉NO₁₀

Color and Shape: White To Off-White

Molecular weight: 503.50

Ref: TR-N285010

Naloxone 3-b-D-Glucuronide (1 mg/ml in DMSO)

Controlled Product

CAS: 22135-79-1

Formula: C₂₅H₂₉NO₁₀

Color and Shape: Single Solution

Molecular weight: 503.50

Ref: TR-KIT0065

Naloxone-d5 3-β-D-Glucuronide (1.0mg/ml in Acetonitrile)

Controlled Product

CAS: 22135-79-1

Formula: C₂₅H₂₄D₅NO₁₀

Color and Shape: Single Solution

Molecular weight: 508.53

Ref: TR-KIT6395

Naloxone 3-β-D-glucuronide

Controlled Product

CAS: 22135-79-1

Please enquire for more information about Naloxone 3-β-D-glucuronide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₂₅H₂₉NO₁₀

Purity: Min. 95%

Molecular weight: 503.51 g/mol

Ref: 3D-MN09682

Naloxone 3-β-D-Glucuronide

CAS: 22135-79-1

Formula: C₂₅H₂₉NO₁₀

Molecular weight: 503.5

Ref: ST-EA-CP-N37022