CAS 22140-20-1

5'-Adenylic acid,2-(methylthio)-

Description:

5'-Adenylic acid, 2-(methylthio)-, also known as 2-methylthioadenosine monophosphate (MTA), is a nucleoside analog characterized by the presence of a methylthio group at the 2-position of the adenine base. This compound is a derivative of adenosine monophosphate (AMP) and plays a significant role in various biological processes, particularly in the metabolism of sulfur-containing compounds. MTA is involved in the methionine salvage pathway and is known to have implications in cellular signaling and regulation. It is soluble in water and exhibits properties typical of nucleotides, such as the ability to participate in enzymatic reactions and serve as a substrate for kinases. The presence of the methylthio group can influence its biological activity and interactions with enzymes and receptors. MTA is also studied for its potential therapeutic applications, particularly in cancer research and as a modulator of immune responses. Overall, 5'-Adenylic acid, 2-(methylthio)- is a significant compound in biochemistry with diverse roles in cellular metabolism.

Formula: C₁₁H₁₆N₅O₇PS

Synonyms:

• Adenosine,2-(methylthio)-, 5'-(dihydrogen phosphate) (8CI)
• 2-MeSAMP
• 2-Methylthio-AMP
• 2-Methylthioadenosine 5'-monophosphate
• 2-Methylthioadenosine 5'-phosphate

[(2R,3S,4R,5R)-5-(6-amino-2-methylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

CAS: 22140-20-1

Formula: C₁₁H₁₆N₅O₇PS

Purity: 99%

Molecular weight: 393.3128

Ref: IN-DA003AQV

2-Methylthioadenosine 5-monophosphate

CAS: 22140-20-1

Molecular weight: 393.31 (anhydrous)

Ref: 7W-GN7642

2-Methylthioadenosine 5-monophosphate

CAS: 22140-20-1

2-Methylthioadenosine 5-monophosphate (2MTA) is an intermediate in purine metabolism that can be synthesized from adenosine monophosphate and methyl mercaptan. 2MTA inhibits the platelet aggregation by inhibiting the function of the P2Y12 receptor, which is a member of the G protein-coupled receptor family. It has been shown to inhibit tumor growth and tumor vasculature, as well as to induce apoptosis in cancer cells. 2MTA also has antiplatelet activity, which may be due to its ability to inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2).

Formula: C₁₁H₁₆N₅O₇PS

Purity: Min. 95%

Molecular weight: 393.31 g/mol

Ref: 3D-NM10203