CAS 22144-77-0: (-)-Cytochalasin D

Description: (-)-Cytochalasin D is a naturally occurring alkaloid derived from various species of fungi, particularly from the genus *Helminthosporium*. It is known for its ability to inhibit actin polymerization, which plays a crucial role in various cellular processes, including cell division, motility, and shape maintenance. The compound exhibits a complex structure characterized by a lactone ring and multiple functional groups, contributing to its biological activity. As a potent cytoskeletal disruptor, (-)-Cytochalasin D has been extensively studied for its effects on cell morphology and movement, making it a valuable tool in cell biology research. It is often used in laboratory settings to investigate the dynamics of the cytoskeleton and its implications in various physiological and pathological processes. Additionally, due to its biological properties, (-)-Cytochalasin D has potential applications in cancer research and therapeutic development, although its use is limited by its toxicity and the need for careful handling in experimental contexts.

Formula: C₃₀H₃₇NO₆

InChI: InChI=1/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9-,15-14-/t17-,18+,22-,23-,24+,25-,26+,29+,30?/m1/s1

InChI key: InChIKey=SDZRWUKZFQQKKV-JHADDHBZSA-N

SMILES: O=C(OC1C=CC(O)(C(=O)C(C)CC=CC2C(O)C(=C)C(C)C3C(NC(=O)C123)CC=4C=CC=CC4)C)C

Synonyms:

• (3R,3aS,4R,6R,6aS,7Z,10R,12S,13Z,15S)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
• (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(Acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione
• (7E,13E)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
• (7E,13Z)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
• 1H-Cycloundec[d]isoindole-1,11(2H)-dione, 15-(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-
• 1H-Cycloundec[d]isoindole-1,11(2H)-dione, 15-(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, [3S-(3R*,3aS*,4R*,6R*,6aS*,7E,10R*,12S*,13E,15S*,15aS*)]-
• 3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
• Cytochalasin D, Zygusporium mansonii
• NSC 209835
• Zygosporin A
• [11]Cytochalasa-6(12),13,19-triene-1,17-dione, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E,21R)-
• cytochalasin D

Cytochalasin D

CAS: 22144-77-0

• Formula: C₃₀H₃₇NO₆
• Purity: By hplc: 99.79% (Typical Value in Batch COA)
• Color and Shape: white powder
• Molecular weight: 507.62g/mol

Cytochalasin D

CAS: 22144-77-0

• Formula: C₃₀H₃₇NO₆
• Purity: ≥ 97.0%
• Color and Shape: White powder
• Molecular weight: 507.62

Cytochalasin D

CAS: 22144-77-0

Cytochalasin D inhibits actin, chondrogenesis, fertilization, tumor growth, and phagocytosis; may increase B16 melanoma metastasis.

• Formula: C₃₀H₃₇NO₆
• Color and Shape: Needles From Acetone-Petroleum Ether Physical Description Needles Or Fluffy White Powder (Ntp 1992)
• Molecular weight: 507.62

Cytochalasin D

CAS: 22144-77-0

• Formula: C₃₀H₃₇NO₆
• Purity: 95%~99%
• Molecular weight: 507.627

Cytochalasin D

CAS: 22144-77-0

Inhibits actin polymerization

• Formula: C₃₀H₃₇NO₆
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 507.62 g/mol