CAS 2215927-89-0

ERK-MYD88 interaction inhibitor 1

Description:

ERK-MYD88 interaction inhibitor 1, identified by its CAS number 2215927-89-0, is a small molecule designed to inhibit the interaction between the ERK (extracellular signal-regulated kinase) pathway and MYD88 (myeloid differentiation primary response 88), a key adaptor protein in the Toll-like receptor signaling pathway. This compound is of interest in the field of cancer research and immunology due to its potential to modulate inflammatory responses and tumor progression. The inhibition of this interaction may lead to altered signaling pathways that can affect cell proliferation, survival, and differentiation. As a research tool, it is typically evaluated in vitro and in vivo to assess its efficacy and mechanism of action. The compound's physicochemical properties, such as solubility, stability, and bioavailability, are crucial for its application in biological studies. Further research is necessary to fully elucidate its therapeutic potential and safety profile in clinical settings.

Formula: C₂₂H₂₁N₅O₂

Synonyms:

• ERK-MYD88 interaction inhibitor 1

ERK-MYD88 interaction inhibitor 1

CAS: 2215927-89-0

ERK-MYD88 Interaction Inhibitor 1, an agent that disrupts the interaction between ERK and MYD88, has demonstrated the ability to trigger an HRI-mediated integrated stress response (ISR) that specifically promotes immunogenic cell apoptosis (apoptosis) in cancer cells. Additionally, in models using Lewis lung cancer mice, this compound has been shown to stimulate anti-tumor T cell responses, thereby exhibiting significant anti-tumor activity.

Formula: C₂₂H₂₁N₅O₂

Color and Shape: Solid

Molecular weight: 387.43

Ref: TM-T200225