CAS 221664-05-7

2,3-Dinor-8-isoPGF2α

Description:

2,3-Dinor-8-isoPGF2α is a synthetic prostaglandin analog that is derived from the metabolism of prostaglandin F2α (PGF2α). It is characterized by its unique structure, which includes modifications to the prostaglandin backbone that enhance its biological activity and stability. This compound is known for its potent vasodilatory effects and its role in various physiological processes, including inflammation and reproductive functions. It is often studied for its potential therapeutic applications, particularly in cardiovascular and reproductive health. The compound is typically used in research settings to explore its effects on smooth muscle contraction and its interactions with specific receptors. Additionally, 2,3-Dinor-8-isoPGF2α may exhibit varying degrees of activity depending on the biological context, making it a valuable tool for understanding prostaglandin signaling pathways. As with many prostaglandin derivatives, its stability and solubility can influence its bioavailability and efficacy in biological systems.

Formula: C₁₈H₃₀O₅

InChI: InChI=1S/C18H30O5/c1-2-3-4-7-13(19)10-11-15-14(16(20)12-17(15)21)8-5-6-9-18(22)23/h5-6,10-11,13-17,19-21H,2-4,7-9,12H2,1H3,(H,22,23)/b6-5-,11-10+/t13-,14-,15+,16-,17+/m0/s1

InChI key: InChIKey=IDKLJIUIJUVJNR-JSEKUSAISA-N

SMILES: C(/C=C\CC(O)=O)[C@H]1[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C[C@@H]1O

Synonyms:

• 2,3-Dinor iPF2α-III
• 3-Pentenoic acid, 5-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octenyl]cyclopentyl]-, (3Z)-
• 2,3-Dinor-8-isoPGF2α
• 3-Pentenoic acid, 5-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]cyclopentyl]-, (3Z)-
• (3Z)-5-[(1S,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]cyclopentyl]-3-pentenoic acid

Prostaglandine (2,3-Di-nor-8-isoprostaglandin F2α)

CAS: 221664-05-7

Formula: C₁₈H₃₀O₅

Molecular weight: 326.43

Ref: 7W-GP3253

2,3-Dinor iPF2α-III

Controlled Product

CAS: 221664-05-7

Formula: C₁₈H₃₀O₅

Color and Shape: Neat

Molecular weight: 326.428

Ref: TR-P838650

2,3-dinor-8-iso Prostaglandin F2α

CAS: 221664-05-7

8-isoProstaglandin F2α (8-isoPGF2α; 8-isoprostane) is a byproduct of non-specific lipid peroxidation, resembling prostaglandin in structure. In humans and rats, its metabolite, 12,3-dinor-8-isoPGF2α, is formed following exogenous administration of 8-isoPGF2α, which is converted to 2,3-dinor-8-isoPGF1α and 2,3-dinor-8-isoPGF2α. Additionally, rat hepatocytes can further break down 8-isoPGF2α into a β-oxidation product, 2,3,4,5-tetranor-8-isoPGF2α. The metabolite, 2,3-dinor-8-isoPGF2α, is normally found in human urine at concentrations of 200-300 pg/ml. Its levels rise in conditions associated with oxidative stress, such as smoking, demonstrating a correlation with the concentration of its precursor, 8-isoPGF2α.

Formula: C₁₈H₃₀O₅

Color and Shape: Solid

Molecular weight: 326.4

Ref: TM-T84593

2,3-Dinor iPF2α-III-d9

Controlled Product

CAS: 221664-05-7

Formula: C₁₈D₉H₂₁O₅

Color and Shape: Neat

Molecular weight: 335.483

Ref: TR-P838652