CAS 2216746-87-9

4-((3R,5S)-5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoic Acid

Controlled Product

CAS: 2216746-87-9

Applications 4-((3R,5S)-5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoic Acid is an impurity compound of Valsartan (V095750). Valsartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)

Formula: C₂₂H₂₃NO₄

Color and Shape: Neat

Molecular weight: 365.422

Ref: TR-B398720

Sacubitril Impurity 19

CAS: 2216746-87-9

Sacubitril Impurity 19 is a drug product that is used as an analytical standard for the purity and concentration of sacubitril. It is also used as an impurity in API manufacture. Sacubitril Impurity 19 is a natural metabolite of sacubitril, which is synthesized from the chemical reaction between sacubitril and hydroxypropyl-beta-cyclodextrin. The impurity has been shown to be eliminated through metabolism studies in rats. Sacubitril Impurity 19 can be found at a concentration of up to 0.2% in commercial samples of sacubitril. It may be present at levels up to 10% in medicinal products containing sacubitril.

Purity: Min. 95%

Ref: 3D-IS181158

Sacubitril Impurity 80

CAS: 2216746-87-9

Formula: C₂₂H₂₃NO₄

Molecular weight: 365.43

Ref: ST-EA-CP-S18080