CAS 221877-54-9: Zotarolimus
Description:Zotarolimus, with the CAS number 221877-54-9, is a synthetic macrolide compound that belongs to the class of immunosuppressive agents. It is primarily used in the medical field as a drug-eluting stent coating to prevent restenosis in coronary arteries after angioplasty. Zotarolimus functions by inhibiting the proliferation of smooth muscle cells and modulating the immune response, which helps to reduce the risk of arterial blockage. The compound exhibits a mechanism of action similar to that of sirolimus, targeting the mammalian target of rapamycin (mTOR) pathway, which is crucial for cell growth and metabolism. Zotarolimus is characterized by its lipophilic nature, which enhances its ability to adhere to stent surfaces and release gradually over time. Its pharmacokinetics involve a relatively long half-life, allowing for sustained therapeutic effects. Safety and efficacy profiles have been established through clinical studies, making it a valuable tool in interventional cardiology. However, like all medications, it may have potential side effects and contraindications that need to be considered in clinical practice.
Formula:C52H79N5O12
InChI:InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1
InChI key:InChIKey=CGTADGCBEXYWNE-JUKNQOCSSA-N
SMILES:O=C1OC(CC(=O)C(C=C(C)C(O)C(OC)C(=O)C(C)CC(C=CC=CC=C(C)C(OC)CC2OC(O)(C(=O)C(=O)N3CCCCC13)C(C)CC2)C)C)C(C)CC4CCC(N5N=NN=C5)C(OC)C4
- Synonyms:
- (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin
- 42-(1-Tetrazolyl)rapamycin
- A 179578
- Abt 578
- Endeavor
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Resolute
- Unii-H4gxr80ize
- Zotarolimus
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- See more synonyms
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
- Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
- Unii-H4gxr80ize
