CAS 221877-54-9

Zotarolimus

Description:

Zotarolimus, with the CAS number 221877-54-9, is a synthetic macrolide compound that belongs to the class of immunosuppressive agents. It is primarily used in the medical field as a drug-eluting stent coating to prevent restenosis in coronary arteries after angioplasty. Zotarolimus functions by inhibiting the proliferation of smooth muscle cells and modulating the immune response, which helps to reduce the risk of arterial blockage. The compound exhibits a mechanism of action similar to that of sirolimus, targeting the mammalian target of rapamycin (mTOR) pathway, which is crucial for cell growth and metabolism. Zotarolimus is characterized by its lipophilic nature, which enhances its ability to adhere to stent surfaces and release gradually over time. Its pharmacokinetics involve a relatively long half-life, allowing for sustained therapeutic effects. Safety and efficacy profiles have been established through clinical studies, making it a valuable tool in interventional cardiology. However, like all medications, it may have potential side effects and contraindications that need to be considered in clinical practice.

Formula:C₅₂H₇₉N₅O₁₂

InChI:InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1

InChI key:InChIKey=CGTADGCBEXYWNE-JUKNQOCSSA-N

SMILES:O(C)[C@H]1[C@](CC[C@@H](C[C@@H](C)[C@]2(OC(=O)[C@]3(N(C(=O)C(=O)[C@]4(O)O[C@](C[C@H](OC)\C(\C)=C\C=C\C=C\[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)\C(\C)=C\[C@@H](C)C(=O)C2)(CC[C@H]4C)[H])CCCC3)[H])[H])C1)(N5C=NN=N5)[H]

Synonyms:

(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin
42-(1-Tetrazolyl)rapamycin
A 179578
Abt 578
Endeavor
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Resolute
Unii-H4gxr80ize
Zotarolimus
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
ABT-578;A-179578;ABT578;A179578;ABT 578;A 179578
(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin Zotarolimus(ABT-578) A 179578 Resolute
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
ZotaroliMus(ABT-578)
Zotarolimus, &gt
ZotaroliMus, >90%
ZOTAROLIMUS USP/EP/BP
ZOTAROLIMUS Impurities
ZotaroliMus API
42-deoxy-42-(1H-tetrazol-1-yl)-(42S)-Rapamycin
CS-1162
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
See more synonyms

Purity (%)

100

Found 7 products.

+ Info
Zotarolimus
CAS:
- 221877-54-9
Formula:C₅₂H₇₉N₅O₁₂
Purity:95%
Color and Shape:Solid
Molecular weight:966.2100
Ref: IN-DA00BF84
1mg
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5mg
162.00€
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Zotarolimus
CAS:
- 221877-54-9
Zotarolimus
Purity:≥95%
Molecular weight:966.21g/mol
Ref: 54-BUP04934
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Zotarolimus
CAS:
- 221877-54-9
Formula:C₅₂H₇₉N₅O₁₂
Color and Shape:Off-White Solid
Molecular weight:966.23
Ref: 4Z-Z-141
5mg
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10mg
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25mg
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Zotarolimus
CAS:
- 221877-54-9
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).
Formula:C₅₂H₇₉N₅O₁₂
Purity:95% - 98.01%
Color and Shape:Solid
Molecular weight:966.21
Ref: TM-T6033
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Zotarolimus-d3
CAS:
- 221877-54-9
Formula:C₅₂H₇₆D₃N₅O₁₂
Molecular weight:969.23
Ref: 4Z-Z-142
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Zotarolimus
CAS:
- 221877-54-9
Inhibitor of immunophilin FKBP12 and mTOR signalling with immunosuppressant activity. Zotarolimus inhibits proliferation of endothelial cells and smooth muscle cells and is employed in vascular interventional therapies.
Formula:C₅₂H₇₉N₅O₁₂
Purity:Min. 95%
Color and Shape:White Powder
Molecular weight:966.21 g/mol
Ref: 3D-FZ28788
2mg
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Zotarolimus-d3, >90% (contains d0)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 221877-54-9
Formula:C₅₂D₃H₇₆N₅O₁₂
Color and Shape:Neat
Molecular weight:969.229
Ref: TR-Z700802
2500µg
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