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CAS 221877-56-1

:

(42S)-42-Deoxy-42-(2H-tetrazol-2-yl)rapamycin

Description:
(42S)-42-Deoxy-42-(2H-tetrazol-2-yl)rapamycin, identified by its CAS number 221877-56-1, is a derivative of rapamycin, a macrolide compound known for its immunosuppressive and anti-proliferative properties. This substance features a tetrazole moiety, which enhances its biological activity and solubility. The compound exhibits a complex structure characterized by a large lactone ring and multiple functional groups, contributing to its pharmacological effects. It is primarily studied for its potential applications in cancer therapy and organ transplantation, as it inhibits the mTOR (mechanistic target of rapamycin) pathway, which is crucial for cell growth and proliferation. The presence of the tetrazole group may also influence its binding affinity and selectivity towards specific biological targets. As with many pharmaceutical compounds, its stability, solubility, and bioavailability are key characteristics that determine its efficacy and safety profile in therapeutic applications. Further research is ongoing to fully elucidate its mechanisms of action and potential clinical uses.
Formula:C52H79N5O12
InChI:InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-54-30-53-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1
InChI key:InChIKey=IURNHYDSJVLLPN-JUKNQOCSSA-N
SMILES:O(C)[C@H]1[C@](CC[C@@H](C[C@@H](C)[C@]2(OC(=O)[C@]3(N(C(=O)C(=O)[C@]4(O)O[C@](C[C@H](OC)\C(\C)=C\C=C\C=C\[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)\C(\C)=C\[C@@H](C)C(=O)C2)(CC[C@H]4C)[H])CCCC3)[H])[H])C1)(N5N=CN=N5)[H]
Synonyms:
  • Rapamycin, 42-deoxy-42-(2H-tetrazol-2-yl)-, (42S)-
  • 42-(2-Tetrazolyl)rapamycin
  • (42S)-42-Deoxy-42-(2H-tetrazol-2-yl)rapamycin
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Found 2 products.
  • 42-(2-Tetrazolyl)rapamycin
    Targetmol
    + Info

    42-(2-Tetrazolyl)rapamycin

    CAS:
    42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog.
    Formula:C52H79N5O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:966.21

    Ref: TM-T10158

    50mg
    898.00€
  • 42-(2-Tetrazolyl)rapamycin
    Biosynth
    + Info

    42-(2-Tetrazolyl)rapamycin

    CAS:
    42-(2-Tetrazolyl)rapamycin is an immunophilin-binding compound, which is derived from the natural product rapamycin. It is a semi-synthetic derivative designed to enhance the properties of the parent compound. As a macrolide, it is sourced from a bacterium called *Streptomyces hygroscopicus*. The mode of action involves binding to FKBP12, forming a complex that inhibits the mammalian target of rapamycin (mTOR), a critical kinase in cell growth, proliferation, and survival pathways.
    Formula:C52H79N5O12
    Purity:Min. 95%
    Molecular weight:966.2 g/mol

    Ref: 3D-WIA87756

    10mg
    835.00€
    25mg
    1,283.00€
    50mg
    1,998.00€