CAS 22195-34-2

Guanadrel sulfate

Description:

Guanadrel sulfate is a chemical compound primarily recognized for its pharmacological properties, particularly as an antihypertensive agent. It is a sulfate salt derived from guanadrel, which is a derivative of guanidine. The compound functions by inhibiting sympathetic nervous system activity, leading to vasodilation and a subsequent decrease in blood pressure. Guanadrel sulfate is typically administered in oral form and is known for its ability to reduce peripheral resistance. In terms of its chemical characteristics, it is a white to off-white crystalline powder that is soluble in water, making it suitable for formulation in various pharmaceutical preparations. The compound's mechanism of action involves the modulation of neurotransmitter release, particularly norepinephrine, which plays a crucial role in regulating vascular tone. While effective in managing hypertension, guanadrel sulfate may also present side effects, including dizziness and fatigue, necessitating careful monitoring during treatment. Overall, its unique properties make it a significant compound in the field of cardiovascular pharmacotherapy.

Formula: C₁₀H₁₉N₃O₂H₂O₄S

InChI: InChI=1S/C10H19N3O2.H2O4S/c11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10;1-5(2,3)4/h8H,1-7H2,(H4,11,12,13);(H2,1,2,3,4)

InChI key: InChIKey=MFSAPVOEKNVUEU-UHFFFAOYSA-N

SMILES: C(NC(=N)N)C1OC2(OC1)CCCCC2.S(=O)(=O)(O)O

Synonyms:

• (1,4-Dioxaspiro(4.5)dec-2-ylmethyl)guanidine sulfate (2:1)
• Guanadrel sulfate [USAN]
• Guanidine, N-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)-, sulfate (2:1)
• U 28288D
• Anarel
• Guanidine (1,4-dioxaspiro(4.5)dec-2-ylmethyl)-, sulfate (2:1)
• Guanadrel sulfate
• Hylorel
• Guanadrel sulfate
• CL 1388R
• UNII-MT147RMO91
• Hyloride
• HSDB 6536
• 1,4-Dioxaspiro[4.5]decane, guanidine deriv.
• U 28,288D

Guanadrel Hemisulfate

Controlled Product

CAS: 22195-34-2

Formula: C₁₀H₁₉N₃O₂·H₂O₄S

Color and Shape: Neat

Molecular weight: 524.632

Ref: TR-G813500

Guanadrel hemisulfate

CAS: 22195-34-2

Guanadrel hemisulfate is a pharmaceutical preparation that is used to treat chronic bronchitis. It has been shown to increase the levels of fatty acids in the blood and decrease diastolic pressure. Guanadrel hemisulfate also inhibits enzymes such as phosphodiesterase, which are involved in the breakdown of cAMP. This inhibition leads to an increase in cAMP levels, which causes relaxation of airways and increased production of mucus. Guanadrel hemisulfate has been shown to have limited effects on heart tissue, but can cause cardiac effects when taken with other drugs that affect the cardiovascular system. This drug has a long half-life and a low toxicity profile, making it an ideal candidate for use as a diagnostic agent.

Formula: C₂₀H₄₀N₆O₈S

Purity: Min. 95%

Molecular weight: 524.6 g/mol

Ref: 3D-XAA19534

Guanadrel Sulfate

CAS: 22195-34-2

Guanadrel Sulfate, a postganglionic blocker, is stored in neurons via the norepinephrine pump.

Formula: C₁₀H₂₁N₃O₆S

Color and Shape: White To Off-White Crystalline Powder

Molecular weight: 311.35

Ref: TM-T9097L