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CAS 222030-63-9

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Combretastatin A4 phosphate

Description:
Combretastatin A4 phosphate is a synthetic derivative of combretastatin A4, which is a natural product derived from the bark of the African willow tree, Combretum caffrum. This compound is primarily known for its potent anti-cancer properties, particularly its ability to inhibit tubulin polymerization, leading to disruption of the microtubule network in cancer cells. As a phosphate prodrug, Combretastatin A4 phosphate is designed to enhance solubility and bioavailability, facilitating its use in therapeutic applications. It is typically administered intravenously and has shown promise in preclinical and clinical studies for treating various solid tumors. The compound is characterized by its ability to induce tumor vascular collapse, thereby starving tumors of their blood supply. Additionally, it has a relatively low toxicity profile compared to traditional chemotherapeutics, making it an attractive candidate for cancer treatment. However, ongoing research is necessary to fully understand its pharmacokinetics, optimal dosing regimens, and potential side effects in diverse patient populations.
Formula:C18H21O8P
InChI:InChI=1S/C18H21O8P/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3/h5-11H,1-4H3,(H2,19,20,21)/b6-5-
InChI key:InChIKey=WDOGQTQEKVLZIJ-WAYWQWQTSA-N
SMILES:O(P(=O)(O)O)C1=C(OC)C=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=C1
Synonyms:
  • Fosbretabulin
  • Combretastatin A4 phosphate
  • Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1-(dihydrogen phosphate)
  • Combretastatin A-4P
  • Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, dihydrogen phosphate
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