CAS 2222-07-3: Cucurbitacin I

Description: Cucurbitacin I is a triterpenoid compound belonging to the cucurbitacin family, which is primarily found in various plants, particularly in the Cucurbitaceae family, such as cucumbers and gourds. It is known for its bitter taste and has been studied for its potential pharmacological properties, including anti-inflammatory, anticancer, and anti-parasitic effects. The molecular structure of Cucurbitacin I features a complex tetracyclic framework, which contributes to its biological activity. This compound exhibits cytotoxicity against various cancer cell lines, making it a subject of interest in cancer research. Additionally, Cucurbitacin I has been investigated for its effects on signaling pathways, particularly those involved in cell proliferation and apoptosis. However, due to its toxicity, its use in therapeutic applications is approached with caution. As with many natural compounds, the extraction and purification processes can influence its efficacy and safety profile, necessitating further research to fully understand its potential benefits and risks in medicinal applications.

Formula: C₃₀H₄₂O₇

InChI: InChI=1S/C30H42O7/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3/b12-11+/t17-,19-,20+,23+,27+,28-,29+,30+/m1/s1

InChI key: InChIKey=NISPVUDLMHQFRQ-MKIKIEMVSA-N

SMILES: O=C(C=CC(O)(C)C)C(O)(C)C1C(O)CC2(C)C3CC=C4C(C=C(O)C(=O)C4(C)C)C3(C(=O)CC12C)C

Synonyms:

• (23E)-2,16,20,25-tetrahydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene-1,11,22-trione
• (4R,9beta,16alpha,23E)-2,16,20,25-tetrahydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene-1,11,22-trione
• (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
• 1,2-Dehydroelatericin A
• 19-Nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione, 9-methyl-2,16,20,25-tetrahydroxy-
• 19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione, 2,16α,20,25-tetrahydroxy-9-methyl-
• 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9beta,10alpha,16alpha)-
• 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9beta,10alpha,16alpha)- (VAN) (9CI)
• 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9β,10α,16α,23E)-
• 2,16alpha,20,25-Tetrahydroxy-9beta-methyl-10alpha-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
• 2,16α,20,25-tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
• Cucurbitacine (I)
• Elatericin B
• Jsi-124
• Nsc 112167
• Nsc 521777
• Cucurbitacin I

Cucurbitacin I

CAS: 2222-07-3

Cucurbitacin I analytical standard provided with w/w absolute assay, to be used for quantitative titration.

• Formula: C₃₀H₄₂O₇
• Purity: (HPLC) ≥95%
• Color and Shape: Powder
• Molecular weight: 514.67

Cucurbitacin I

CAS: 2222-07-3

• Formula: C₃₀H₄₂O₇
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 514.6503

Cucurbitacin I hydrate

CAS: 2222-07-3

• Formula: C₃₀H₄₂O₇·xH₂O
• Purity: ≥ 97.0%
• Color and Shape: White to off-white solid or powder
• Molecular weight: 514.65 (anhydrous)

Cucurbitacin I

CAS: 2222-07-3

• Purity: 98.19%
• Molecular weight: 514.65g/mol

Cucurbitacin I

CAS: 2222-07-3

• Formula: C₃₀H₄₂O₇
• Purity: 95%~99%
• Molecular weight: 514.659

Cucurbitacin I

CAS: 2222-07-3

Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.

• Formula: C₃₀H₄₂O₇
• Purity: 96.69% - 98.2%
• Color and Shape: Solid
• Molecular weight: 514.65

Cucurbitacin I

CAS: 2222-07-3

• Formula: C₃₀H₄₂O₇
• Molecular weight: 514.66

Cucurbitacin i

CAS: 2222-07-3

Ketone alcohol

• Formula: C₃₀H₄₂O₇
• Purity: ≥ 98.0 % (HPLC)
• Color and Shape: Powder
• Molecular weight: 514.66

Cucurbitacin I

CAS: 2222-07-3

Inhibitor of STAT3/JAK2 signaling; radiosensitizer

• Formula: C₃₀H₄₂O₇
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 514.65 g/mol

Cucurbitacin I - Bio-X ™

CAS: 2222-07-3

This product is part of our Bio-X ™ Range. These products are aimed at life …

• Formula: C₃₀H₄₂O₇
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 514.65 g/mol

Cucurbitacin I

CAS: 2222-07-3

• Formula: C₃₀H₄₂O₇
• Color and Shape: Off-White
• Molecular weight: 514.65