CAS 2222-07-3

Cucurbitacin I

Description:

Cucurbitacin I is a triterpenoid compound belonging to the cucurbitacin family, which is primarily found in various plants, particularly in the Cucurbitaceae family, such as cucumbers and gourds. It is known for its bitter taste and has been studied for its potential pharmacological properties, including anti-inflammatory, anticancer, and anti-parasitic effects. The molecular structure of Cucurbitacin I features a complex tetracyclic framework, which contributes to its biological activity. This compound exhibits cytotoxicity against various cancer cell lines, making it a subject of interest in cancer research. Additionally, Cucurbitacin I has been investigated for its effects on signaling pathways, particularly those involved in cell proliferation and apoptosis. However, due to its toxicity, its use in therapeutic applications is approached with caution. As with many natural compounds, the extraction and purification processes can influence its efficacy and safety profile, necessitating further research to fully understand its potential benefits and risks in medicinal applications.

Formula: C₃₀H₄₂O₇

InChI: InChI=1S/C30H42O7/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3/b12-11+/t17-,19-,20+,23+,27+,28-,29+,30+/m1/s1

InChI key: InChIKey=NISPVUDLMHQFRQ-MKIKIEMVSA-N

SMILES: C[C@]12[C@@](C)([C@@]([C@@](C(/C=C/C(C)(C)O)=O)(C)O)([C@H](O)C1)[H])CC(=O)[C@]3(C)[C@]2(CC=C4[C@]3(C=C(O)C(=O)C4(C)C)[H])[H]

Synonyms:

• (23E)-2,16,20,25-tetrahydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene-1,11,22-trione
• (4R,9beta,16alpha,23E)-2,16,20,25-tetrahydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene-1,11,22-trione
• (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
• 1,2-Dehydroelatericin A
• 19-Nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione, 9-methyl-2,16,20,25-tetrahydroxy-
• 19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione, 2,16α,20,25-tetrahydroxy-9-methyl-
• 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9beta,10alpha,16alpha)-
• 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9beta,10alpha,16alpha)- (VAN) (9CI)
• 19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9β,10α,16α,23E)-
• 2,16alpha,20,25-Tetrahydroxy-9beta-methyl-10alpha-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
• 2,16α,20,25-tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
• Cucurbitacine (I)
• Elatericin B
• Jsi-124
• Nsc 112167
• Nsc 521777

Cucurbitacin I

CAS: 2222-07-3

Cucurbitacin I analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₃₀H₄₂O₇

Purity: (HPLC) ≥95%

Color and Shape: Powder

Molecular weight: 514.67

Ref: 11-0021S

Cucurbitacin I

CAS: 2222-07-3

Formula: C₃₀H₄₂O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 514.6503

Ref: IN-DA019FUI

Cucurbitacin I

CAS: 2222-07-3

Cucurbitacin I

Purity: ≥95%

Molecular weight: 514.65g/mol

Ref: 54-BUP08791

Cucurbitacin I hydrate

CAS: 2222-07-3

Formula: C₃₀H₄₂O₇·xH₂O

Purity: ≥ 97.0%

Color and Shape: White to off-white solid or powder

Molecular weight: 514.65 (anhydrous)

Ref: 7W-GK6661

Cucurbitacin I

CAS: 2222-07-3

Formula: C₃₀H₄₂O₇

Purity: 95%~99%

Molecular weight: 514.659

Ref: BP-BP3979

Cucurbitacin I

CAS: 2222-07-3

Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.

Formula: C₃₀H₄₂O₇

Purity: 96.69% - 99.8%

Color and Shape: Solid

Molecular weight: 514.65

Ref: TM-TQ0196

Cucurbitacin I

CAS: 2222-07-3

Formula: C₃₀H₄₂O₇

Molecular weight: 514.66

Ref: 4Z-C-266003

Cucurbitacin i

CAS: 2222-07-3

Ketone alcohol

Formula: C₃₀H₄₂O₇

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 514.66

Ref: 5G-89464

Cucurbitacin I - Bio-X ™

Controlled Product

CAS: 2222-07-3

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₃₀H₄₂O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 514.65 g/mol

Ref: 3D-BC300056

Cucurbitacin I

Controlled Product

CAS: 2222-07-3

Inhibitor of STAT3/JAK2 signaling; radiosensitizer

Formula: C₃₀H₄₂O₇

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 514.65 g/mol

Ref: 3D-FC64989

Cucurbitacin I

CAS: 2222-07-3

Purity: ≥98%

Molecular weight: 514.659

Ref: 10-F979757

Cucurbitacin I

Controlled Product

CAS: 2222-07-3

Formula: C₃₀H₄₂O₇

Color and Shape: Off-White

Molecular weight: 514.65

Ref: TR-C838813