CAS 2222981-61-3

2-Propenamide, N-[4-[1-(3-aminobenzoyl)-4-piperidinyl]butyl]-3-(3-pyridinyl)-, (2E)-

Description:

2-Propenamide, N-[4-[1-(3-aminobenzoyl)-4-piperidinyl]butyl]-3-(3-pyridinyl)-, commonly referred to by its CAS number 2222981-61-3, is a synthetic organic compound characterized by its complex structure, which includes an amide functional group and multiple aromatic and heterocyclic rings. This compound features a propenamide backbone, indicating the presence of a double bond between the second and third carbon atoms of the amide group. The molecule contains a piperidine ring, which contributes to its potential biological activity, and a pyridine ring that may enhance its solubility and reactivity. The presence of an amino group suggests potential for hydrogen bonding, which can influence its interactions in biological systems. This compound may be of interest in medicinal chemistry, particularly for its potential applications in drug development, given its structural features that could interact with biological targets. However, specific properties such as solubility, melting point, and biological activity would require empirical data for comprehensive characterization.

Formula: C₂₄H₃₀N₄O₂

Synonyms:

• Nampt-IN-15
• 2-Propenamide, N-[4-[1-(3-aminobenzoyl)-4-piperidinyl]butyl]-3-(3-pyridinyl)-, (2E)-
• (E)-N-(4-(1-(3-Aminobenzoyl)piperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide

Nampt-IN-15

CAS: 2222981-61-3

Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.

Formula: C₂₄H₃₀N₄O₂

Color and Shape: Solid

Molecular weight: 406.52

Ref: TM-T201167