CAS 2226133-29-3

6-Benzothiazolecarboxylic acid, 2-[(2R)-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methyl]-2-methyl-1-piperazinyl]-4-methoxy-

Formula: C₂₇H₂₆Cl₂N₄O₄S

Synonyms:

• 6-Benzothiazolecarboxylic acid, 2-[(2R)-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methyl]-2-methyl-1-piperazinyl]-4-methoxy-
• HPG1860

HPG1860

CAS: 2226133-29-3

HPG1860, an agonist of the farnesoid X receptor (FXR), induces luminescence in reporter gene assays utilizing HEK293T cells expressing human FXR, with an EC50 value of 18 nM. In vivo studies demonstrate that HPG1860 (administered at 1, 3, or 10 mg/kg daily) reduces serum alanine aminotransferase (ALT) and total cholesterol levels in a mouse model of non-alcoholic steatohepatitis (NASH), which was induced by a high-fat diet and carbon tetrachloride (CCl4). Additionally, this compound decreases hepatic inflammation, fat levels, and fibrosis.

Formula: C₂₇H₂₆Cl₂N₄O₄S

Molecular weight: 573.49

Ref: TM-T201349