CAS 222631-44-9

3,4-Pyrrolidinediol,2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, hydrochloride(1:1), (2S,3S,4R,5R)-

Description:

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, hydrochloride (1:1), with the CAS number 222631-44-9, is a chemical compound characterized by its complex structure, which includes a pyrrolidine ring and a pyrrolo-pyrimidine moiety. This compound is typically a white to off-white solid and is soluble in water due to the presence of hydroxyl and amino groups, which enhance its hydrophilicity. The hydrochloride form indicates that it is a salt, which can influence its stability and solubility properties. The stereochemistry of the compound is specified as (2S,3S,4R,5R), indicating the specific three-dimensional arrangement of atoms, which is crucial for its biological activity. Such compounds often exhibit pharmacological properties, making them of interest in medicinal chemistry and drug development. However, detailed information regarding its specific applications, biological activity, and safety profile would require further investigation and context from scientific literature.

Formula: C₁₁H₁₆ClN₅O₃

InChI: InChI=1S/C11H15N5O3.ClH/c12-11-8-6(14-3-15-11)4(1-13-8)7-10(19)9(18)5(2-17)16-7;/h1,3,5,7,9-10,13,16-19H,2H2,(H2,12,14,15);1H/t5-,7+,9-,10+;/m1./s1

InChI key: InChIKey=PCCHVYNGFMEGIG-QPAIBFMUSA-N

SMILES: O[C@H]1[C@H](C=2C=3C(NC2)=C(N)N=CN3)N[C@H](CO)[C@H]1O.Cl

Synonyms:

• 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-
• 3,4-Pyrrolidinediol,2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-,monohydrochloride, (2S,3S,4R,5R)- (9CI)
• Bcx 4430
• 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, hydrochloride (1:1), (2S,3S,4R,5R)-
• (2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol monohydrochloride
• BCX 4430 hydrochloride
• (BCX4430
• BCX4430;GALIDESIVIR
• 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-
• Galidesivir HCl
• Galidesivir)
• Immucillin-A hydrochloride
• GALIDESIVIR HYDROCHLORIDE (BCX 4430 HYDROCHLORIDE)

(2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol hydrochloride

CAS: 222631-44-9

(2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol hydrochloride

Purity: 99%

Molecular weight: 301.73g/mol

Ref: 54-OR1065243

BCX 4430

Controlled Product

CAS: 222631-44-9

Applications BCX 4430 is an antiviral drug, an adenosine analog). It is developed by BioCryst Pharmaceuticals with funding from NIAID, originally intended as a treatment for Hepatitis C, but subsequently developed as a potential treatment for deadly filovirus infections such as Ebola virus disease and Marburg virus disease.
References Warren, T., et al.: Nature, 508, 7496 (2014); Kamat, S., et al.: Biochem., 52, 7366 (2013)

Formula: C₁₁H₁₅N₅O₃·ClH

Color and Shape: Neat

Molecular weight: 301.729

Ref: TR-B119190

BCX 4430 hydrochloride

CAS: 222631-44-9

RNA polymerase (RdRp) inhibitor

Formula: C₁₁H₁₅N₅O₃

Purity: Min. 95%

Molecular weight: 265.27 g/mol

Ref: 3D-NB58350

Galidesivir hydrochloride

CAS: 222631-44-9

Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.

Formula: C₁₁H₁₆ClN₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 301.73

Ref: TM-T10491L