CAS 2226941-29-1

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

Description:

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine is a synthetic compound that belongs to the class of staurosporine derivatives, which are known for their potent inhibitory effects on various protein kinases. This compound is characterized by its complex molecular structure, which includes multiple functional groups such as acetyl and demethyl modifications. These modifications can influence its biological activity, solubility, and pharmacokinetic properties. Staurosporine and its derivatives are often studied for their potential therapeutic applications, particularly in cancer treatment, due to their ability to induce apoptosis in cancer cells. The specific structural modifications in 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine may enhance its selectivity and efficacy against certain targets. Additionally, the compound's CAS number, 2226941-29-1, serves as a unique identifier for regulatory and research purposes, facilitating its study in various scientific contexts. Overall, this compound represents a significant area of interest in medicinal chemistry and drug development.

Synonyms:

• 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine

MAP3K5-IN-1

CAS: 2226941-29-1

Compound 7, also known as 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine, serves as an inhibitor of protein kinases, displaying IC50 values of 0.092 μM for PKC-α, 0.26 μM for ROCK, and 0.77 μM for ASK1. Additionally, this compound exhibits significant cytotoxicity towards PC-3 cancer cells, with an IC50 of 0.16 μM [1].

Formula: C₂₈H₂₄N₄O₄

Color and Shape: Solid

Molecular weight: 480.51

Ref: TM-TN7602