CAS 2227587-25-7

GSK3368715 hydrochloride

CAS: 2227587-25-7

GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.

Formula: C₂₀H₃₈N₄O₂·HCl

Color and Shape: Solid

Molecular weight: 403

Ref: TM-T84982