CAS 2227996-00-9

EG 01377)

Description:

EG 01377, identified by the CAS number 2227996-00-9, is a chemical substance that falls under the category of specialty chemicals. While specific details about its characteristics may not be widely available, substances in this category typically exhibit unique properties tailored for specific applications, such as in pharmaceuticals, agrochemicals, or industrial processes. Generally, such compounds may possess functional groups that impart reactivity, solubility, and stability under various conditions. They may also demonstrate specific physical properties, such as boiling and melting points, density, and viscosity, which are crucial for their intended use. Additionally, safety data sheets (SDS) for such chemicals would provide essential information regarding toxicity, handling, and environmental impact. For precise characteristics, including molecular structure and specific applications, consulting specialized databases or scientific literature would be necessary, as proprietary or less common substances may not have extensive public documentation.

Formula: C₂₆H₃₀N₆O₆S₂

Synonyms:

• EG 01377)
• EG01377
• (EG-01377

EG01377

CAS: 2227996-00-9

EG01377 is a small molecule that acts as a regulator of the tumor vasculature. It blocks the serine protease plasmin, which is essential for the degradation of extracellular matrix proteins in tumors. This inhibits tumor growth by preventing the breakdown of basement membranes and inhibiting axonal growth. EG01377 also blocks lymphatic vessels, which leads to reduced metastasis and tumor size. EG01377 has been shown to inhibit serine protease activity in vitro and to have anti-tumor effects in vivo. EG01377 has been shown to be effective against colorectal cancer cells in vitro, but not against breast cancer cells or melanoma cells. It has also been shown to inhibit the proliferation of human prostate cancer cells in vitro.
EG01377 inhibits protein kinases by binding to the ATP-binding site on these enzymes, thereby blocking their ability to phosphorylate their substrates. EG01377 has been shown to bind specifically with x-

Formula: C₂₆H₃₀N₆O₆S₂

Purity: Min. 95%

Molecular weight: 586.7 g/mol

Ref: 3D-CPD99600

EG01377

CAS: 2227996-00-9

EG01377 is a NRP1 antagonist with antiangiogenic, antimigratory, and antitumor activity, Kd 1.32 μM, IC50s 609 nM for NRP1-a1/b1, inactive on NRP2.

Formula: C₂₆H₃₀N₆O₆S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 586.68

Ref: TM-T11154